Ferroportin | SLC40 iron transporter | IUPHAR/BPS Guide to PHARMACOLOGY

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Ferroportin

Target not currently curated in GtoImmuPdb

Target id: 1194

Nomenclature: Ferroportin

Abbreviated Name: IREG1

Systematic Nomenclature: SLC40A1

Family: SLC40 iron transporter

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC40A1 solute carrier family 40 member 1
Mouse - - Slc40a1 solute carrier family 40 (iron-regulated transporter)
Rat - - Slc40a1 solute carrier family 40 member 1
Previous and Unofficial Names
FPN1 | HFE4 | MTP1 | ferroportin 1 | Dusg | CAR1 | cell adhesion regulator | Slc39a1 | solute carrier family 40 member 1 | iron-regulated transporter | solute carrier family 39 (iron-regulated transporter), member 1 | metal transporting protein 1 | SLC11A3 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 | solute carrier family 40 (iron-regulated transporter), member 1 | solute carrier family 40 (iron-regulated transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC40A1 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Fe2+ Hs - -
Stoichiometry
Unknown

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
VIT-2763 Mm Antagonist 8.1 pIC50 2
pIC50 8.1 (IC50 9x10-9 M) [2]
Description: Measuring VIT-2763-induced displacement of hepcidin binding to ferroportin in mouse J774 ells.
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
LY2928057 Hs Binding - - 1
[1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002260 lymphocyte homeostasis IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0048536 spleen development IMP
click arrow to show/hide IEA associations
GO:0060345 spleen trabecula formation IEA

References

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1. Leung DDM, Luan P, Manetta JV, Tang Y, Witcher DR,. (2010) Anti-ferroportin 1 monoclonal antibodies and uses thereof. Patent number: WO2010065496 A1. Assignee: Eli Lilly And Company.. Priority date: 05/12/2008. Publication date: 10/06/2010.

2. Manolova V, Nyffenegger N, Flace A, Altermatt P, Varol A, Doucerain C, Sundstrom H, Dürrenberger F. (2019) Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia. J. Clin. Invest., 130 (1): 491-506. [PMID:31638596]

How to cite this page

SLC40 iron transporter: Ferroportin. Last modified on 17/08/2020. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1194.