Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	10	571	2q32.2	SLC40A1	solute carrier family 40 member 1
Mouse	10	570	1 C1.1	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1
Rat	10	570	9q22	Slc40a1	solute carrier family 40 member 1

Previous and Unofficial Names

FPN1 | HFE4 | MTP1 | ferroportin 1 | CAR1 | cell adhesion regulator | Slc39a1 | solute carrier family 40 member 1 | iron-regulated transporter | solute carrier family 39 (iron-regulated transporter), member 1 | Dusg | metal transporting protein 1 | SLC11A3 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 | solute carrier family 40 (iron-regulated transporter), member 1 | solute carrier family 40 (iron-regulated transporter)

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC40A1 (Hs)
RESOLUTE	SLC40A1 (Hs)
Other databases
Alphafold	Q9NP59 (Hs), Q9JHI9 (Mm), Q923U9 (Rn)
ChEMBL Target	CHEMBL3392948 (Hs), CHEMBL4523462 (Mm)
Ensembl Gene	ENSG00000138449 (Hs), ENSMUSG00000025993 (Mm), ENSRNOG00000003872 (Rn)
Entrez Gene	30061 (Hs), 53945 (Mm)
Human Protein Atlas	ENSG00000138449 (Hs)
KEGG Gene	hsa:30061 (Hs), mmu:53945 (Mm)
OMIM	604653 (Hs)
Pharos	Q9NP59 (Hs)
UniProtKB	Q9NP59 (Hs), Q9JHI9 (Mm), Q923U9 (Rn)
Wikipedia	SLC40A1 (Hs)

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference Fe2+ Hs - -

Stoichiometry
Unknown

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference vamifeport Mm Antagonist 8.1 pIC50 2 ⤷ pIC50 8.1 (IC50 9x10-9 M) [2] Description: Measuring VIT-2763-induced displacement of hepcidin binding to ferroportin in mouse J774 ells.

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference LY2928057 Hs Binding - - 1 ⤷ [1]