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Ferroportin

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Target not currently curated in GtoImmuPdb

Target id: 1194

Nomenclature: Ferroportin

Abbreviated Name: IREG1

Systematic Nomenclature: SLC40A1

Family: SLC40 iron transporter

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 10 571 2q32.2 SLC40A1 solute carrier family 40 member 1
Mouse 10 570 1 C1.1 Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1
Rat 10 570 9q22 Slc40a1 solute carrier family 40 member 1
Previous and Unofficial Names Click here for help
FPN1 | HFE4 | MTP1 | ferroportin 1 | CAR1 | cell adhesion regulator | Slc39a1 | solute carrier family 40 member 1 | iron-regulated transporter | solute carrier family 39 (iron-regulated transporter), member 1 | Dusg | metal transporting protein 1 | SLC11A3 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 | solute carrier family 40 (iron-regulated transporter), member 1 | solute carrier family 40 (iron-regulated transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC40A1 (Hs)
RESOLUTE SLC40A1 (Hs)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Fe2+ Substrate is endogenous in the given species Hs - -
Stoichiometry Click here for help
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
vamifeport Small molecule or natural product Mm Antagonist 8.1 pIC50 2
pIC50 8.1 (IC50 9x10-9 M) [2]
Description: Measuring VIT-2763-induced displacement of hepcidin binding to ferroportin in mouse J774 ells.
Antibodies
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Antibody Sp. Action Value Parameter Reference
LY2928057 Peptide Primary target of this compound Hs Binding - - 1
[1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002260 lymphocyte homeostasis IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0048536 spleen development IMP
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GO:0060345 spleen trabecula formation IEA

References

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1. Leung DDM, Luan P, Manetta JV, Tang Y, Witcher DR,. (2010) Anti-ferroportin 1 monoclonal antibodies and uses thereof. Patent number: WO2010065496 A1. Assignee: Eli Lilly And Company.. Priority date: 05/12/2008. Publication date: 10/06/2010.

2. Manolova V, Nyffenegger N, Flace A, Altermatt P, Varol A, Doucerain C, Sundstrom H, Dürrenberger F. (2019) Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia. J Clin Invest, 130 (1): 491-506. [PMID:31638596]

How to cite this page

SLC40 iron transporter: Ferroportin. Last modified on 17/08/2020. Accessed on 28/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1194.