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Target not currently curated in GtoImmuPdb

Target id: 121

Nomenclature: GPR85

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 370 7q31.1 GPR85 G protein-coupled receptor 85 2
Mouse 7 370 6 A1 Gpr85 G protein-coupled receptor 85 2
Rat 7 370 4q21 Gpr85 G protein-coupled receptor 85 2
Previous and Unofficial Names Click here for help
Srep2 | SREB2 | SREB | Super conserved receptor expressed in brain 2 | PKrCx1
Database Links Click here for help
Specialist databases
GPCRDB gpr85_human (Hs), gpr85_mouse (Mm), gpr85_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution Click here for help
Brain, testis, small intestine, placenta, spleen
Species:  Human
Technique:  Northern blot
References:  2,8
Species:  Human
Technique:  In situ hybridization
References:  7
Species:  Mouse
Technique:  Northern blot
References:  2-3
Neural tissue and macrophages
Species:  Mouse
Technique:  Microarray analysis
References:  6
Upper intestine (muscle-mesenteric nerve layer)
Species:  Mouse
Technique:  RT-PCR
References:  4
Brain and spinal cord
Species:  Rat
Technique:  In situ hybridization
References:  5,7
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions Click here for help
Negative regulation of hippocampal adult neurogenesis and neurogenesis dependent learning and memory
Species:  Mouse
Tissue:  Hippocampus(dentate gyrus)
References:  1
Physiological Consequences of Altering Gene Expression Click here for help
Mice with receptor knockout show enhanced new neuronal survival in dentate gyrus, enhanced ability to discriminate spatial relationships, and significant increase in brain weight.
Species:  Mouse
Tissue:  Brain
Technique:  Gene knockout
References:  1,9
Receptor overexpression leads to decreased new cell proliferation and survival in the dentate gyrus. Morphology deficits in newly generated neurons are seem with ventricular enlargement and behaviour mirroring psychiatric disorders. Mice have decreased ability to discriminate spatial relationships and a reciprocal phenotype to knock out mice in Y-maze working memory tasks. Decreased social interaction, abnormal sensorimotor gating and impaired memory are also seen.
Species:  Mouse
Tissue:  Brain
Technique:  Gene over-expression
References:  1,9
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr85tm1Mima Gpr85tm1Mima/Gpr85tm1Mima
involves: C57BL/6 * CBA
MGI:1927851  MP:0001469 abnormal contextual conditioning behavior PMID: 18413613 
Gpr85tm1Mima Gpr85tm1Mima/Gpr85tm1Mima
involves: C57BL/6 * CBA
MGI:1927851  MP:0001260 increased body weight PMID: 18413613 
Gpr85tm1Mima Gpr85tm1Mima/Gpr85tm1Mima
involves: C57BL/6 * CBA
MGI:1927851  MP:0005238 increased brain size PMID: 18413613 
Gpr85tm1Mima Gpr85tm1Mima/Gpr85tm1Mima
involves: C57BL/6 * CBA
MGI:1927851  MP:0002176 increased brain weight PMID: 18413613 
Clinically-Relevant Mutations and Pathophysiology Comments
3 missense SNPs have been linked to schizophrenia, though are not confirmed as causative: S104F (rs201803332), Y57C (rs201795714) and V46L (rs148433444) [1].
Gene Expression and Pathophysiology Comments
Mouse models with receptor overexpression have been linked to schizophrenia [1].


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1. Chen Q, Kogan JH, Gross AK, Zhou Y, Walton NM, Shin R, Heusner CL, Miyake S, Tajinda K, Tamura K et al.. (2012) SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. Eur J Neurosci, 36 (5): 2597-608. [PMID:22697179]

2. Hellebrand S, Schaller HC, Wittenberger T. (2000) The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. Biochim Biophys Acta, 1493 (1-2): 269-72. [PMID:10978537]

3. Hellebrand S, Wittenberger T, Schaller HC, Hermans-Borgmeyer I. (2001) Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex. Brain Res Gene Expr Patterns, 1 (1): 13-6. [PMID:15018813]

4. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]

5. Jeon J, Kim C, Sun W, Chung H, Park SH, Kim H. (2002) Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor. Biochem Biophys Res Commun, 298 (4): 613-8. [PMID:12408996]

6. Lattin JE, Schroder K, Su AI, Walker JR, Zhang J, Wiltshire T, Saijo K, Glass CK, Hume DA, Kellie S, Sweet MJ. (2008) Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res, 4: 5. [PMID:18442421]

7. Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, Lipska BK, Weinberger DR, Kleinman JE. (2005) A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res Mol Brain Res, 138 (1): 58-69. [PMID:15893849]

8. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun, 272 (2): 576-82. [PMID:10833454]

9. Matsumoto M, Straub RE, Marenco S, Nicodemus KK, Matsumoto S, Fujikawa A, Miyoshi S, Shobo M, Takahashi S, Yarimizu J, Yuri M, Hiramoto M, Morita S, Yokota H, Sasayama T, Terai K, Yoshino M, Miyake A, Callicott JH, Egan MF, Meyer-Lindenberg A, Kempf L, Honea R, Vakkalanka RK, Takasaki J, Kamohara M, Soga T, Hiyama H, Ishii H, Matsuo A, Nishimura S, Matsuoka N, Kobori M, Matsushime H, Katoh M, Furuichi K, Weinberger DR. (2008) The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci USA, 105 (16): 6133-8. [PMID:18413613]


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