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Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 370 | 7q31.1 | GPR85 | G protein-coupled receptor 85 | 2 |
| Mouse | 7 | 370 | 6 A1 | Gpr85 | G protein-coupled receptor 85 | 2 |
| Rat | 7 | 370 | 4q21 | Gpr85 | G protein-coupled receptor 85 | 2 |
| Previous and Unofficial Names |
| Srep2 | SREB2 | SREB | Super conserved receptor expressed in brain 2 | PKrCx1 |
| Database Links |
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| Specialist databases | |
| GPCRdb | gpr85_human (Hs), gpr85_mouse (Mm), gpr85_rat (Rn) |
| Other databases | |
| Alphafold | P60893 (Hs), P60894 (Mm), P60895 (Rn) |
| ChEMBL Target | CHEMBL4523868 (Hs) |
| Ensembl Gene | ENSG00000164604 (Hs), ENSMUSG00000048216 (Mm), ENSRNOG00000024636 (Rn) |
| Entrez Gene | 54329 (Hs), 64450 (Mm), 64020 (Rn) |
| Human Protein Atlas | ENSG00000164604 (Hs) |
| KEGG Gene | hsa:54329 (Hs), mmu:64450 (Mm), rno:64020 (Rn) |
| OMIM | 605188 (Hs) |
| Pharos | P60893 (Hs) |
| RefSeq Nucleotide | NM_018970 (Hs), NM_145066 (Mm), NM_022254 (Rn) |
| RefSeq Protein | NP_061842 (Hs), NP_659503 (Mm), NP_071590 (Rn) |
| UniProtKB | P60893 (Hs), P60894 (Mm), P60895 (Rn) |
| Wikipedia | GPR85 (Hs) |
| Tissue Distribution
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| Expression Datasets |
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology Comments |
| 3 missense SNPs have been linked to schizophrenia, though are not confirmed as causative: S104F (rs201803332), Y57C (rs201795714) and V46L (rs148433444) [1]. |
| Gene Expression and Pathophysiology Comments | |
| Mouse models with receptor overexpression have been linked to schizophrenia [1]. |
1. Chen Q, Kogan JH, Gross AK, Zhou Y, Walton NM, Shin R, Heusner CL, Miyake S, Tajinda K, Tamura K et al.. (2012) SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. Eur J Neurosci, 36 (5): 2597-608. [PMID:22697179]
2. Hellebrand S, Schaller HC, Wittenberger T. (2000) The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. Biochim Biophys Acta, 1493 (1-2): 269-72. [PMID:10978537]
3. Hellebrand S, Wittenberger T, Schaller HC, Hermans-Borgmeyer I. (2001) Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex. Brain Res Gene Expr Patterns, 1 (1): 13-6. [PMID:15018813]
4. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]
5. Jeon J, Kim C, Sun W, Chung H, Park SH, Kim H. (2002) Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor. Biochem Biophys Res Commun, 298 (4): 613-8. [PMID:12408996]
6. Lattin JE, Schroder K, Su AI, Walker JR, Zhang J, Wiltshire T, Saijo K, Glass CK, Hume DA, Kellie S, Sweet MJ. (2008) Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res, 4: 5. [PMID:18442421]
7. Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, Lipska BK, Weinberger DR, Kleinman JE. (2005) A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res Mol Brain Res, 138 (1): 58-69. [PMID:15893849]
8. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun, 272 (2): 576-82. [PMID:10833454]
9. Matsumoto M, Straub RE, Marenco S, Nicodemus KK, Matsumoto S, Fujikawa A, Miyoshi S, Shobo M, Takahashi S, Yarimizu J, Yuri M, Hiramoto M, Morita S, Yokota H, Sasayama T, Terai K, Yoshino M, Miyake A, Callicott JH, Egan MF, Meyer-Lindenberg A, Kempf L, Honea R, Vakkalanka RK, Takasaki J, Kamohara M, Soga T, Hiyama H, Ishii H, Matsuo A, Nishimura S, Matsuoka N, Kobori M, Matsushime H, Katoh M, Furuichi K, Weinberger DR. (2008) The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci USA, 105 (16): 6133-8. [PMID:18413613]
