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Target not currently curated in GtoImmuPdb
Target id: 1254
Nomenclature: protein arginine methyltransferase 3
Abbreviated Name: PRMT3
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 531 | 11p15.1 | PRMT3 | protein arginine methyltransferase 3 | |
Mouse | - | 532 | 7 B4 | Prmt3 | protein arginine N-methyltransferase 3 | |
Rat | - | 528 | 1q22 | Prmt3 | protein arginine methyltransferase 3 |
Database Links | |
Alphafold | O60678 (Hs), Q922H1 (Mm), O70467 (Rn) |
ChEMBL Target | CHEMBL5891 (Hs) |
Ensembl Gene | ENSG00000185238 (Hs), ENSMUSG00000030505 (Mm), ENSRNOG00000014829 (Rn) |
Entrez Gene | 10196 (Hs), 71974 (Mm), 89820 (Rn) |
Human Protein Atlas | ENSG00000185238 (Hs) |
KEGG Gene | hsa:10196 (Hs), mmu:71974 (Mm), rno:89820 (Rn) |
OMIM | 603190 (Hs) |
Pharos | O60678 (Hs) |
SynPHARM |
79359 (in complex with compound 1 [PMID: 22795084]) 82339 (in complex with SGC707) |
UniProtKB | O60678 (Hs), Q922H1 (Mm), O70467 (Rn) |
Wikipedia | PRMT3 (Hs) |
Selected 3D Structures | |||||||||||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Eram MS, Shen Y, Szewczyk MM, Wu H, Senisterra G, Li F, Butler KV, Kaniskan U, Speed BA, dela Sena C et al.. (2015) A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chemical Biology, Just Accepted Manuscript.
2. Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I et al.. (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl, 54 (17): 5166-70. [PMID:25728001]
3. Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F et al.. (2012) An allosteric inhibitor of protein arginine methyltransferase 3. Structure, 20 (8): 1425-35. [PMID:22795084]
2.1.1.- Protein arginine N-methyltransferases: protein arginine methyltransferase 3. Last modified on 11/12/2015. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1254.