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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 491 | 19q13.2 | CYP2B6 | cytochrome P450 family 2 subfamily B member 6 | |
| Previous and Unofficial Names |
| cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 | 1,4-cineole 2-exo-monooxygenase | cytochrome P450, family 2, subfamily B, polypeptide 6 |
| Database Links |
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| Alphafold | P20813 (Hs) |
| BRENDA | 1.14.14.1 |
| ChEMBL Target | CHEMBL4729 (Hs) |
| Ensembl Gene | ENSG00000197408 (Hs) |
| Entrez Gene | 1555 (Hs) |
| Human Protein Atlas | ENSG00000197408 (Hs) |
| KEGG Enzyme | 1.14.14.1 |
| KEGG Gene | hsa:1555 (Hs) |
| OMIM | 123930 (Hs) |
| Pharos | P20813 (Hs) |
| UniProtKB | P20813 (Hs) |
| Wikipedia | CYP2B6 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK. (2013) Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes. Chem Biol Interact, 205 (1): 11-9. [PMID:23777987]
2. Fontana E, Dansette PM, Poli SM. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab, 6 (5): 413-54. [PMID:16248836]
3. Walsky RL, Obach RS. (2007) A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos, 35 (11): 2053-9. [PMID:17682072]
