<i>GPR146</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 133

Nomenclature: GPR146

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 333 7p22.3 GPR146 G protein-coupled receptor 146
Mouse 7 333 5 G1 Gpr146 G protein-coupled receptor 146
Rat 7 333 12q11 Gpr146 G protein-coupled receptor 146
Previous and Unofficial Names
AXOR120 | G-protein coupled receptor PGR8
Database Links
Specialist databases
GPCRDB gp146_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Agonist Comments
Yosten et al. demonstrated inhibition of proinsulin C-peptide-induced stimulation of cFos expression folllowing knockdown of GPR146 in KATOIII cells, suggesting proinsulin C-peptide as an endogenous ligand of the receptor [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G11E
SNP accession: 
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V266M
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 


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1. Yosten GL, Kolar GR, Redlinger LJ, Samson WK. (2013) Evidence for an interaction between proinsulin C-peptide and GPR146. J. Endocrinol., 218 (2): B1-8. [PMID:23759446]


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