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Target not currently curated in GtoImmuPdb

Target id: 1330

Nomenclature: CYP2E1

Family: CYP2 family: drug metabolising subset

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 10q26.3 CYP2E1 cytochrome P450 family 2 subfamily E member 1
Mouse - 493 7 85.94 cM Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1
Rat - 493 1q41 Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1
Previous and Unofficial Names Click here for help
4-nitrophenol 2-hydroxylase | cytochrome P450 2E1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | cytochrome P450, subfamily 2e1 (ethanol-inducible) | cytochrome P450, family 2, subfamily E, polypeptide 1 | cytochrome P450
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 23 [PMID: 17125252] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pKi 2
pKi 7.4 (Ki 4x10-8 M) [2]
12-Imidazolyl-1-dodecanol Small molecule or natural product Hs Inhibition 6.2 pKi 1
pKi 6.2 [1]


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1. Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D et al.. (2020) Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. PLoS One, 15 (7): e0235990. [PMID:32701948]

2. Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem, 49 (24): 6987-7001. [PMID:17125252]


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