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CYP2E1

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Target not currently curated in GtoImmuPdb

Target id: 1330

Nomenclature: CYP2E1

Family: CYP2 family: drug metabolising subset

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 10q26.3 CYP2E1 cytochrome P450 family 2 subfamily E member 1
Mouse - 493 7 85.94 cM Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1
Rat - 493 1q41 Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1
Previous and Unofficial Names Click here for help
4-nitrophenol 2-hydroxylase | cytochrome P450 2E1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | cytochrome P450, subfamily 2e1 (ethanol-inducible) | cytochrome P450, family 2, subfamily E, polypeptide 1 | cytochrome P450
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.14.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 23 [PMID: 17125252] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pKi 2
pKi 7.4 (Ki 4x10-8 M) [2]
12-Imidazolyl-1-dodecanol Small molecule or natural product Hs Inhibition 6.2 pKi 1
pKi 6.2 [1]

References

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1. Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D et al.. (2020) Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. PLoS One, 15 (7): e0235990. [PMID:32701948]

2. Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem, 49 (24): 6987-7001. [PMID:17125252]

Contributors

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