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Target not currently curated in GtoImmuPdb

Target id: 136

Nomenclature: GPR150

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 434 5q15 GPR150 G protein-coupled receptor 150
Mouse 7 427 13 C1 Gpr150 G protein-coupled receptor 150
Rat 7 - 2q11 Gpr150 G protein-coupled receptor 150
Previous and Unofficial Names Click here for help
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution Click here for help
Central nervous system
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  E214Q
Global MAF (%):  16
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 3|16|17|22
Minor allele count:  C=0.156/341
SNP accession: 
Validation:  1000 Genomes
General Comments
Abberant methylation of the GPR150 gene may be a candidate tumor marker [1].


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1. Cai LY, Abe M, Izumi S, Imura M, Yasugi T, Ushijima T. (2007) Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci, 80 (16): 1458-65. [PMID:17303177]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta, 1722 (3): 235-46. [PMID:15777626]


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