<i>GPR150</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 136

Nomenclature: GPR150

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 434 5q15 GPR150 G protein-coupled receptor 150
Mouse 7 427 13 C1 Gpr150 G protein-coupled receptor 150
Rat 7 - 2q11 Gpr150 G protein-coupled receptor 150
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
Central nervous system
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  E214Q
Global MAF (%):  16
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 3|16|17|22
Minor allele count:  C=0.156/341
SNP accession: 
Validation:  1000 Genomes
General Comments
Abberant methylation of the GPR150 gene may be a candidate tumor marker [1].


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1. Cai LY, Abe M, Izumi S, Imura M, Yasugi T, Ushijima T. (2007) Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci., 80 (16): 1458-65. [PMID:17303177]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]


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