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Target not currently curated in GtoImmuPdb

Target id: 1389

Nomenclature: 15-LOX-2

Family: Lipoxygenases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 676 17p13.1 ALOX15B arachidonate 15-lipoxygenase type B
Mouse - 677 11 B3 Alox8 arachidonate 8-lipoxygenase
Rat - 677 10q24 Alox15b arachidonate 15-lipoxygenase, type B
Previous and Unofficial Names Click here for help
15-lipoxygenase 2 | 15-LOX-B | arachidonate 15-lipoxygenase type II | 8S-lipoxygenase | 8S-LOX | arachidonate 15-lipoxygenase, type B | arachidonate 15-lipoxygenase
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number: Arachidonic acid + O2 = 15S-HPETE

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MLS000536924 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 5.6 pKi 1
pKi 5.6 (Ki 2.5x10-6 M) [1]
compound 21n [PMID: 17656086] Small molecule or natural product Hs Inhibition 7.3 pIC50 2
pIC50 7.3 (IC50 5.1x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration


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1. Jameson 2nd JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. (2014) A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. PLoS ONE, 9 (8): e104094. [PMID:25111178]

2. Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, Robl JA. (2007) Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg Med Chem Lett, 17 (18): 5115-20. [PMID:17656086]


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