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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 676 | 17p13.1 | ALOX15B | arachidonate 15-lipoxygenase type B | |
Mouse | - | 677 | 11 B3 | Alox8 | arachidonate 8-lipoxygenase | |
Rat | - | 677 | 10q24 | Alox15b | arachidonate 15-lipoxygenase, type B |
Previous and Unofficial Names ![]() |
15-lipoxygenase 2 | 15-LOX-B | arachidonate 15-lipoxygenase type II | 8S-lipoxygenase | 8S-LOX | arachidonate 15-lipoxygenase, type B | arachidonate 15-lipoxygenase |
Database Links ![]() |
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Alphafold | O15296 (Hs), O35936 (Mm), Q8K4F2 (Rn) |
BRENDA | 1.13.11.33 |
CATH/Gene3D | 2.60.60.20 |
ChEMBL Target | CHEMBL2457 (Hs), CHEMBL4879413 (Mm), CHEMBL3289 (Rn) |
Ensembl Gene | ENSG00000179593 (Hs), ENSMUSG00000020891 (Mm), ENSRNOG00000007778 (Rn) |
Entrez Gene | 247 (Hs), 11688 (Mm), 266604 (Rn) |
Human Protein Atlas | ENSG00000179593 (Hs) |
KEGG Enzyme | 1.13.11.33 |
KEGG Gene | hsa:247 (Hs), mmu:11688 (Mm), rno:266604 (Rn) |
OMIM | 603697 (Hs) |
Pharos | O15296 (Hs) |
UniProtKB | O15296 (Hs), O35936 (Mm), Q8K4F2 (Rn) |
Wikipedia | ALOX15B (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Jameson 2nd JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. (2014) A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. PLoS ONE, 9 (8): e104094. [PMID:25111178]
2. Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, Robl JA. (2007) Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg Med Chem Lett, 17 (18): 5115-20. [PMID:17656086]