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GPR161

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Target not currently curated in GtoImmuPdb

Target id: 141

Nomenclature: GPR161

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 529 1q24.2 GPR161 G protein-coupled receptor 161
Mouse 7 545 1 72.64 cM Gpr161 G protein-coupled receptor 161
Rat 7 528 13q23 Gpr161 G protein-coupled receptor 161
Previous and Unofficial Names Click here for help
G-protein coupled receptor RE2
Database Links Click here for help
Specialist databases
GPCRdb gp161_human (Hs), gp161_mouse (Mm)
Other databases
Alphafold Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn)
ChEMBL Target CHEMBL4523894 (Hs)
Ensembl Gene ENSG00000143147 (Hs), ENSMUSG00000040836 (Mm), ENSRNOG00000003073 (Rn)
Entrez Gene 23432 (Hs), 240888 (Mm), 289180 (Rn)
Human Protein Atlas ENSG00000143147 (Hs)
KEGG Gene hsa:23432 (Hs), mmu:240888 (Mm), rno:289180 (Rn)
OMIM 612250 (Hs)
Pharos Q8N6U8 (Hs)
RefSeq Nucleotide NM_153832 (Hs), NM_001081126 (Mm)
RefSeq Protein NP_722561 (Hs), NP_001074595 (Mm)
UniProtKB Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn)
Wikipedia GPR161 (Hs)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CART(55-102) {Sp: Human} Peptide Rn Binding - - 3
⤷ [3]
Description: Binding of rat peptide to Gpr162 in rat INS-1 832/13 pancreatic islet cells.
Tissue Distribution Click here for help
Mouse embryo. Expressed from E8.5 to E11.5. At E8.0-E9.5, expression was restricted to the lateral neural folds of the neural plate. Gpr161 is expressed at all examined stages of lens development: lens pit (E10.5), lens vesicle (E11.5), primary lens fiber cells (E12.5), and differentiating secondary lens fiber cells (E14.5). At E12.5 and E14.5, Gpr161 transcripts are restricted to differentiating lens fiber cells and are absent from the proliferating anterior lens epithelium. Gpr161 is also expressed in a number of other structures from E9.5 to E12.5, including the ventricular zone of the developing CNS (E9.5-E11.5), the fore and hindlimbs (E12.5), and the retina (E10.5-E14.5).
Species:  Mouse
Technique:  RT-PCR, In situ hybridization
References:  4
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Comments
GPR161 is required for right-left patterning in zebrafish development via modulation of Ca2+ in cells surrounding Kupffer's vesicles [2].
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J		 MGI:2685054  MP:0001303 abnormal lens morphology
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J		 MGI:2685054  MP:0004837 abnormal neural fold formation PMID: 1731393 
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J		 MGI:2685054  MP:0000373 belly spot
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J		 MGI:2685054  MP:0001304 cataracts
Gpr161vl|Modvl3MOLF/EiJ Gpr161vl/Gpr161vl,Modvl3MOLF/EiJ/Modvl3MOLF/EiJ
involves: C3H/HeSnJ * MOLF/EiJ		 MGI:2685054  MGI:3784974  MP:0001304 cataracts PMID: 18250320 
Gpr161vl|Modvl3C3H/HeSnJ|Modvl3MOLF/EiJ Gpr161vl/Gpr161vl,Modvl3C3H/HeSnJ/Modvl3MOLF/EiJ
involves: C3H/HeSnJ * MOLF/EiJ		 MGI:2685054  MGI:3784974  MP:0001304 cataracts PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * C57BL/6J		 MGI:2685054  MP:0000755 hindlimb paralysis PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * CAST/Ei		 MGI:2685054  MP:0000755 hindlimb paralysis PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J		 MGI:2685054  MP:0003054 spina bifida
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * C57BL/6J		 MGI:2685054  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * CAST/Ei		 MGI:2685054  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl1C3H/HeSnJ Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C3H/HeSnJ
involves: C3H/HeSnJ * C57BL/6J		 MGI:2685054  MGI:3784970  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl1C3H/HeSnJ|Modvl1C57BL/6J Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C57BL/6J
involves: C3H/HeSnJ * C57BL/6J		 MGI:2685054  MGI:3784970  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl2C3H/HeSnJ Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2C3H/HeSnJ
involves: C3H/HeSnJ * CAST/EiJ		 MGI:2685054  MGI:3784972  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl2C3H/HeSnJ|Modvl2CAST/EiJ Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2CAST/EiJ
involves: C3H/HeSnJ * CAST/EiJ		 MGI:2685054  MGI:3784972  MP:0003054 spina bifida PMID: 18250320 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Irritable bowel syndrome
Disease Ontology: DOID:9778
Comments:  Mucosal expression of GPR161 expression was decreased after infection with Campylobacter jejuni in postinfectious irritable bowel syndrome.
References:  5
Clinically-Relevant Mutations and Pathophysiology Comments
A C-terminal truncation (deletion) mutation in Gpr61 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant. Foxe3 is a genetic modifier that interacts with GPR161 to regulate lens development [4]. The mutated receptor is associated with cataract, spina bifidia and white belly spot phenotypes in mice [1].
Biologically Significant Variant Comments
The vacuolated lens C-terminal GPR161 truncation mutation affects receptor mediated endocytosis [4].

References

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1. Korstanje R, Desai J, Lazar G, King B, Rollins J, Spurr M, Joseph J, Kadambi S, Li Y, Cherry A, Matteson PG, Paigen B, Millonig JH. (2008) Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects. Physiol Genomics, 35 (3): 296-304. [PMID:18796533]

2. Leung T, Humbert JE, Stauffer AM, Giger KE, Chen H, Tsai HJ, Wang C, Mirshahi T, Robishaw JD. (2008) The orphan G protein-coupled receptor 161 is required for left-right patterning. Dev Biol, 323 (1): 31-40. [PMID:18755178]

3. Lindqvist A, Abels M, Shcherbina L, Ngara M, Kryvokhyzha D, Chriett S, Riva M, Fajul A, Barghouth M, Luan C et al.. (2023) GPR162 is a beta cell CART receptor. iScience, 26 (12): 108416. [PMID:38077141]

4. Matteson PG, Desai J, Korstanje R, Lazar G, Borsuk TE, Rollins J, Kadambi S, Joseph J, Rahman T, Wink J, Benayed R, Paigen B, Millonig JH. (2008) The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc Natl Acad Sci USA, 105 (6): 2088-93. [PMID:18250320]

5. Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG et al.. (2013) Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut, 62 (7): 985-94. [PMID:22684480]

Contributors

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