<i>GPR162</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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GPR162

Target not currently curated in GtoImmuPdb

Target id: 142

Nomenclature: GPR162

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 588 12p13 GPR162 G protein-coupled receptor 162
Mouse 7 588 6 F2 Gpr162 G protein-coupled receptor 162
Rat 7 575 4q42 Gpr162 G protein-coupled receptor 162
Previous and Unofficial Names
GRCA
Database Links
Specialist databases
GPCRDB gp162_human (Hs), gp162_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Central nervous system, lung, sexual organs
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G450R
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 6|2|3|3
Minor allele count:  A=0.032/70
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R459G
Global MAF (%):  15
Subpopulation MAF (%):  AFR|AMR|EUR: 1|23|30
Minor allele count:  G=0.146/319
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
References:  1

References

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1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al.. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res., 14 (10B): 2121-7. [PMID:15489334]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]

Contributors

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