<i>GPR171</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 143

Nomenclature: GPR171

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 319 3q25.1 GPR171 G protein-coupled receptor 171 2
Mouse 7 319 3 D Gpr171 G protein-coupled receptor 171
Rat 7 326 2q31 Gpr171 G protein-coupled receptor 171
Previous and Unofficial Names
G-protein coupled receptor H963 | platelet activating receptor homolog
Database Links
Specialist databases
GPCRDB gp171_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Agonist Comments
GPR171 has been shown to be activated by endogenous peptide BigLEN. This receptor-peptide interaction is believed to be involved in regulating feeding and metabolism responses [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  I283V
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|3|13|1
Minor allele count:  C=0.047/103
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
General Comments
GPR171 is excluded as a candidate gene of Usher syndrome Type 3 [3].


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1. Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD et al.. (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc. Natl. Acad. Sci. U.S.A., 110 (40): 16211-6. [PMID:24043826]

2. Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V et al.. (1997) A genetic selection for isolating cDNAs encoding secreted proteins. Gene, 198 (1-2): 289-96. [PMID:9370294]

3. Joensuu T, Hämäläinen R, Yuan B, Johnson C, Tegelberg S, Gasparini P, Zelante L, Pirvola U, Pakarinen L, Lehesjoki AE et al.. (2001) Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Am. J. Hum. Genet., 69 (4): 673-84. [PMID:11524702]


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