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Microtubule associated serine/threonine kinase 3

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Target not currently curated in GtoImmuPdb

Target id: 1512

Nomenclature: Microtubule associated serine/threonine kinase 3

Abbreviated Name: MAST3

Family: MAST family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1309 19p13.11 MAST3 microtubule associated serine/threonine kinase 3
Mouse - 1321 8 B3.3 Mast3 microtubule associated serine/threonine kinase 3
Rat - 1305 16p14 Mast3 microtubule associated serine/threonine kinase 3
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3)
PDB Id:  3KHF
Resolution:  1.2Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 23916259] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.4x10-7 M) [1]

References

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1. Li B, Cociorva OM, Nomanbhoy T, Weissig H, Li Q, Nakamura K, Liyanage M, Zhang MC, Shih AY, Aban A et al.. (2013) Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett, 23 (18): 5217-22. [PMID:23916259]

How to cite this page

MAST family: Microtubule associated serine/threonine kinase 3. Last modified on 23/09/2015. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1512.