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Target not currently curated in GtoImmuPdb
Target id: 1558
Nomenclature: calcium/calmodulin-dependent protein kinase II delta subunit
Abbreviated Name: CaMK2δ
Family: CAMK2 family
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 499 | 4q26 | CAMK2D | calcium/calmodulin dependent protein kinase II delta | |
Mouse | - | 499 | 3 G1 | Camk2d | calcium/calmodulin-dependent protein kinase II, delta | |
Rat | - | 533 | 2q42 | Camk2d | calcium/calmodulin-dependent protein kinase II delta |
Previous and Unofficial Names |
caM kinase II subunit delta | CAMK1 | Camk2 | Camki | caMK-II subunit delta | CAMKD | calcium/calmodulin-dependent protein kinase II |
Database Links | |
Alphafold | Q13557 (Hs), Q6PHZ2 (Mm), P15791 (Rn) |
BRENDA | 2.7.11.17 |
ChEMBL Target | CHEMBL2801 (Hs), CHEMBL4296090 (Rn) |
Ensembl Gene | ENSG00000145349 (Hs), ENSMUSG00000053819 (Mm), ENSRNOG00000011589 (Rn) |
Entrez Gene | 817 (Hs), 108058 (Mm), 24246 (Rn) |
Human Protein Atlas | ENSG00000145349 (Hs) |
KEGG Enzyme | 2.7.11.17 |
KEGG Gene | hsa:817 (Hs), mmu:108058 (Mm), rno:24246 (Rn) |
OMIM | 607708 (Hs) |
Pharos | Q13557 (Hs) |
RefSeq Nucleotide | NM_001221 (Hs), NM_001025439 (Mm), NM_012519 (Rn) |
RefSeq Protein | NP_001212 (Hs), NP_001020609 (Mm), NP_001020610 (Mm), NP_076302 (Mm), NP_036651 (Rn) |
UniProtKB | Q13557 (Hs), Q6PHZ2 (Mm), P15791 (Rn) |
Wikipedia | CAMK2D (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,8 |
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: CAMK2D | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3 |
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Target used in screen: CaMKIIδ/CAMK2d | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immuno Process Associations | ||
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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
4. Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA et al.. (2014) Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett, 6 (1): 25-30. [PMID:25589925]
5. Lu Q, Chen Z, Perumattam J, Wang DX, Liang W, Xu YJ, Do S, Bonaga L, Higaki J, Dong H et al.. (2008) Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation. Bioorg Med Chem Lett, 18 (7): 2399-403. [PMID:18337095]
6. Mavunkel B, Xu YJ, Goyal B, Lim D, Lu Q, Chen Z, Wang DX, Higaki J, Chakraborty I, Liclican A et al.. (2008) Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett, 18 (7): 2404-8. [PMID:18334293]
7. Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. (2010) Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol, 8 (7): e1000426. [PMID:20668654]
8. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
CAMK2 family: calcium/calmodulin-dependent protein kinase II delta subunit. Last modified on 07/11/2016. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1558.