Puromycin-sensitive aminopeptidase | M1: Aminopeptidase N | IUPHAR/BPS Guide to PHARMACOLOGY

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Puromycin-sensitive aminopeptidase

Target not currently curated in GtoImmuPdb

Target id: 1575

Nomenclature: Puromycin-sensitive aminopeptidase

Family: M1: Aminopeptidase N

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 919 17q12-q21 NPEPPS aminopeptidase puromycin sensitive
Mouse - 920 11 D Npepps aminopeptidase puromycin sensitive
Rat - - 10q31 Npepps aminopeptidase puromycin sensitive
Previous and Unofficial Names
metalloproteinase MP100 | PSA
Database Links
Specialist databases
MEROPS M01.010 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.14

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ANTAQ Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.9x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0000209 protein polyubiquitination TAS

References

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1. Kakuta H, Koiso Y, Nagasawa K, Hashimoto Y. (2003) Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg. Med. Chem. Lett., 13 (1): 83-6. [PMID:12467622]

How to cite this page

M1: Aminopeptidase N: Puromycin-sensitive aminopeptidase. Last modified on 28/07/2015. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1575.