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Puromycin-sensitive aminopeptidase

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Target not currently curated in GtoImmuPdb

Target id: 1575

Nomenclature: Puromycin-sensitive aminopeptidase

Family: M1: Aminopeptidase N

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 919 17q21.32 NPEPPS aminopeptidase puromycin sensitive
Mouse - 920 11 60.95 cM Npepps aminopeptidase puromycin sensitive
Rat - - 10q31 Npepps aminopeptidase puromycin sensitive
Previous and Unofficial Names Click here for help
metalloproteinase MP100 | PSA
Database Links Click here for help
Specialist databases
MEROPS M01.010 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.11.14

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ANTAQ Small molecule or natural product Primary target of this compound Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.9x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0000209 protein polyubiquitination TAS

References

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1. Kakuta H, Koiso Y, Nagasawa K, Hashimoto Y. (2003) Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett, 13 (1): 83-6. [PMID:12467622]

How to cite this page

M1: Aminopeptidase N: Puromycin-sensitive aminopeptidase. Last modified on 28/07/2015. Accessed on 27/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1575.