Carboxypeptidase A1 (pancreatic) | M14: Carboxypeptidase A | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Carboxypeptidase A1 (pancreatic)

Target not currently curated in GtoImmuPdb

Target id: 1587

Nomenclature: Carboxypeptidase A1 (pancreatic)

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 419 7q32 CPA1 carboxypeptidase A1
Mouse - 419 6 B1 Cpa1 carboxypeptidase A1
Rat - 419 4q22 Cpa1 carboxypeptidase A1
Previous and Unofficial Names
carboxypeptidase A1 (pancreatic) | carboxypeptidase A1, pancreatic
Database Links
Specialist databases
MEROPS M14.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
S-BMPA Bt Inhibition 8.1 pKi 2
pKi 8.1 (Ki 7.8x10-9 M) [2]
compound 1b [PMID: 18078750] Hs Inhibition 6.5 pKi 1
pKi 6.5 (Ki 3.1x10-7 M) [1]
View species-specific inhibitor tables


Show »

1. Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite. Bioorg. Med. Chem. Lett., 18 (2): 732-7. [PMID:18078750]

2. KIm DH, Kim YJ. (1993) Synthesis and inhibitory activity of optically active 2-benzyl-3-mercaptopropanoic acid against carboxypeptidase A. Bioorg. Med. Chem. Lett., 3 (12): 2681-2684.

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase A1 (pancreatic). Last modified on 29/07/2015. Accessed on 10/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY,