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Carboxypeptidase A1 (pancreatic)

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Target not currently curated in GtoImmuPdb

Target id: 1587

Nomenclature: Carboxypeptidase A1 (pancreatic)

Family: M14: Carboxypeptidase A

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 419 7q32.2 CPA1 carboxypeptidase A1
Mouse - 419 6 12.52 cM Cpa1 carboxypeptidase A1, pancreatic
Rat - 419 4q22 Cpa1 carboxypeptidase A1
Previous and Unofficial Names Click here for help
carboxypeptidase A1 (pancreatic) | carboxypeptidase A1, pancreatic
Database Links Click here for help
Specialist databases
MEROPS M14.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.17.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
S-BMPA Small molecule or natural product Ligand has a PDB structure Bt Inhibition 8.1 pKi 2
pKi 8.1 (Ki 7.8x10-9 M) [2]
compound 1b [PMID: 18078750] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.5 pKi 1
pKi 6.5 (Ki 3.1x10-7 M) [1]
View species-specific inhibitor tables

References

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1. Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite. Bioorg Med Chem Lett, 18 (2): 732-7. [PMID:18078750]

2. KIm DH, Kim YJ. (1993) Synthesis and inhibitory activity of optically active 2-benzyl-3-mercaptopropanoic acid against carboxypeptidase A. Bioorg Med Chem Lett, 3 (12): 2681-2684.

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase A1 (pancreatic). Last modified on 29/07/2015. Accessed on 26/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1587.