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Carboxypeptidase A1 (pancreatic)

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Target not currently curated in GtoImmuPdb

Target id: 1587

Nomenclature: Carboxypeptidase A1 (pancreatic)

Family: M14: Carboxypeptidase A

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 419 7q32.2 CPA1 carboxypeptidase A1
Mouse - 419 6 12.52 cM Cpa1 carboxypeptidase A1, pancreatic
Rat - 419 4q22 Cpa1 carboxypeptidase A1
Previous and Unofficial Names Click here for help
carboxypeptidase A1 (pancreatic) | carboxypeptidase A1, pancreatic
Database Links Click here for help
Specialist databases
MEROPS M14.001 (Hs)
Other databases
Alphafold P15085 (Hs), Q7TPZ8 (Mm), P00731 (Rn)
BRENDA 3.4.17.1
CATH/Gene3D 3.30.70.340
ChEMBL Target CHEMBL2088 (Hs)
Ensembl Gene ENSG00000091704 (Hs), ENSMUSG00000054446 (Mm), ENSRNOG00000010725 (Rn)
Entrez Gene 1357 (Hs), 109697 (Mm), 24269 (Rn)
Human Protein Atlas ENSG00000091704 (Hs)
KEGG Enzyme 3.4.17.1
KEGG Gene hsa:1357 (Hs), mmu:109697 (Mm), rno:24269 (Rn)
OMIM 114850 (Hs)
Pharos P15085 (Hs)
RefSeq Nucleotide NM_001868 (Hs), NM_025350 (Mm), NM_016998 (Rn)
RefSeq Protein NP_001859 (Hs), NP_079626 (Mm), NP_058694 (Rn)
UniProtKB P15085 (Hs), Q7TPZ8 (Mm), P00731 (Rn)
Wikipedia CPA1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
S-BMPA Small molecule or natural product Ligand has a PDB structure Bt Inhibition 8.1 pKi 2
⤷ pKi 8.1 (Ki 7.8x10-9 M) [2]
compound 1b [PMID: 18078750] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.5 pKi 1
⤷ pKi 6.5 (Ki 3.1x10-7 M) [1]
View species-specific inhibitor tables

References

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1. Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite. Bioorg Med Chem Lett, 18 (2): 732-7. [PMID:18078750]

2. KIm DH, Kim YJ. (1993) Synthesis and inhibitory activity of optically active 2-benzyl-3-mercaptopropanoic acid against carboxypeptidase A. Bioorg Med Chem Lett, 3 (12): 2681-2684.

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase A1 (pancreatic). Last modified on 29/07/2015. Accessed on 04/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1587.