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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 423 | 13q14.13 | CPB2 | carboxypeptidase B2 | |
Mouse | - | 422 | 14 D3 | Cpb2 | carboxypeptidase B2 | |
Rat | - | 422 | 15q11 | Cpb2 | carboxypeptidase B2 |
Database Links ![]() |
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Specialist databases | |
MEROPS | M14.009 (Hs) |
Other databases | |
Alphafold | Q96IY4 (Hs), Q9JHH6 (Mm), Q9EQV9 (Rn) |
BRENDA | 3.4.17.20 |
CATH/Gene3D | 3.30.70.340 |
ChEMBL Target | CHEMBL3419 (Hs), CHEMBL4879512 (Rn) |
Ensembl Gene | ENSG00000080618 (Hs), ENSMUSG00000021999 (Mm), ENSRNOG00000010935 (Rn) |
Entrez Gene | 1361 (Hs), 56373 (Mm), 113936 (Rn) |
Human Protein Atlas | ENSG00000080618 (Hs) |
KEGG Enzyme | 3.4.17.20 |
KEGG Gene | hsa:1361 (Hs), mmu:56373 (Mm), rno:113936 (Rn) |
OMIM | 603101 (Hs) |
Pharos | Q96IY4 (Hs) |
RefSeq Nucleotide | NM_001872 (Hs), NM_019775 (Mm), NM_053617 (Rn) |
RefSeq Protein | NP_001863 (Hs), NP_062749 (Mm), NP_446069 (Rn) |
UniProtKB | Q96IY4 (Hs), Q9JHH6 (Mm), Q9EQV9 (Rn) |
Wikipedia | CPB2 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]
2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem, 50 (24): 6095-103. [PMID:17990866]
3. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett, 20 (1): 92-6. [PMID:19954973]
M14: Carboxypeptidase A: Carboxypeptidase B2 (plasma). Last modified on 29/07/2015. Accessed on 12/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1594.