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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 458 | 10q24.2 | CPN1 | carboxypeptidase N subunit 1 | |
Mouse | - | 457 | 19 36.68 cM | Cpn1 | carboxypeptidase N, polypeptide 1 | |
Rat | - | 457 | 1q54 | Cpn1 | carboxypeptidase N subunit 1 |
Database Links ![]() |
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Specialist databases | |
MEROPS | M14.004 (Hs) |
Other databases | |
Alphafold | P15169 (Hs), Q9JJN5 (Mm), Q9EQV8 (Rn) |
BRENDA | 3.4.17.3 |
ChEMBL Target | CHEMBL4713 (Hs) |
Ensembl Gene | ENSG00000120054 (Hs), ENSMUSG00000025196 (Mm), ENSRNOG00000013439 (Rn) |
Entrez Gene | 1369 (Hs), 93721 (Mm), 365466 (Rn) |
Human Protein Atlas | ENSG00000120054 (Hs) |
KEGG Enzyme | 3.4.17.3 |
KEGG Gene | hsa:1369 (Hs), mmu:93721 (Mm), rno:365466 (Rn) |
OMIM | 603103 (Hs) |
Pharos | P15169 (Hs) |
RefSeq Nucleotide | NM_001308 (Hs), NM_030703 (Mm) |
RefSeq Protein | NP_001299 (Hs), NP_109628 (Mm) |
UniProtKB | P15169 (Hs), Q9JJN5 (Mm), Q9EQV8 (Rn) |
Wikipedia | CPN1 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Phenotypes, Alleles and Disease Models ![]() |
Mouse data from MGI | ||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]
2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem, 50 (24): 6095-103. [PMID:17990866]
M14: Carboxypeptidase A: Carboxypeptidase N, polypeptide 1. Last modified on 29/07/2015. Accessed on 12/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1597.