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Carboxypeptidase N, polypeptide 1

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Target not currently curated in GtoImmuPdb

Target id: 1597

Nomenclature: Carboxypeptidase N, polypeptide 1

Family: M14: Carboxypeptidase A

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 458 10q24.2 CPN1 carboxypeptidase N subunit 1
Mouse - 457 19 36.68 cM Cpn1 carboxypeptidase N, polypeptide 1
Rat - 457 1q54 Cpn1 carboxypeptidase N subunit 1
Previous and Unofficial Names Click here for help
anaphylatoxin inactivator | arginine carboxypeptidase | carboxypeptidase K | kininase I | lysine carboxypeptidase | carboxypeptidase N catalytic chain | Cpn | carboxypeptidase N
Database Links Click here for help
Specialist databases
MEROPS M14.004 (Hs)
Other databases
Alphafold P15169 (Hs), Q9JJN5 (Mm), Q9EQV8 (Rn)
BRENDA 3.4.17.3
ChEMBL Target CHEMBL4713 (Hs)
Ensembl Gene ENSG00000120054 (Hs), ENSMUSG00000025196 (Mm), ENSRNOG00000013439 (Rn)
Entrez Gene 1369 (Hs), 93721 (Mm), 365466 (Rn)
Human Protein Atlas ENSG00000120054 (Hs)
KEGG Enzyme 3.4.17.3
KEGG Gene hsa:1369 (Hs), mmu:93721 (Mm), rno:365466 (Rn)
OMIM 603103 (Hs)
Pharos P15169 (Hs)
RefSeq Nucleotide NM_001308 (Hs), NM_030703 (Mm)
RefSeq Protein NP_001299 (Hs), NP_109628 (Mm)
UniProtKB P15169 (Hs), Q9JJN5 (Mm), Q9EQV8 (Rn)
Wikipedia CPN1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.3

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SQ-24,798 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.7 pKi 2
⤷ pKi 8.7 (Ki 2x10-9 M) [2]
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.8 pIC50 1
⤷ pIC50 7.8 (IC50 1.7x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
C3ar1tm1Raw|Cpn1tm1Raw C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
B6.129-C3ar1 Cpn1		 MGI:1097680  MGI:2135874  MP:0005088 increased acute inflammation PMID: 19414808 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Carboxypeptidase N deficiency
OMIM: 212070

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem, 50 (24): 6095-103. [PMID:17990866]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase N, polypeptide 1. Last modified on 29/07/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1597.