Dipeptidyl-peptidase 7 | S28: Lysosomal Pro-Xaa carboxypeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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Dipeptidyl-peptidase 7

Target not currently curated in GtoImmuPdb

Target id: 1605

Nomenclature: Dipeptidyl-peptidase 7

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 9q34.3 DPP7 dipeptidyl peptidase 7
Mouse - 506 2 A3 Dpp7 dipeptidylpeptidase 7
Rat - 500 3p13 Dpp7 dipeptidylpeptidase 7
Previous and Unofficial Names
DPPII | dipeptidyl aminopeptidase II | dipeptidyl peptidase 2 | dipeptidyl peptidase II | Dpp2 | quiescent cell proline dipeptidase | QPP | dipeptidyl-peptidase 7
Database Links
Specialist databases
MEROPS S28.002 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.14.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UAMC00039 Hs Inhibition 10.1 pKi 1
pKi 10.1 (Ki 8.2x10-11 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS

References

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1. Maes MB, Martinet W, Schrijvers DM, Van der Veken P, De Meyer GR, Augustyns K, Lambeir AM, Scharpé S, De Meester I. (2006) Dipeptidyl peptidase II and leukocyte cell death. Biochem. Pharmacol., 72 (1): 70-9. [PMID:16725115]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Dipeptidyl-peptidase 7. Last modified on 21/11/2013. Accessed on 26/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1605.