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Folate hydrolase (prostate-specific membrane antigen) 1

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Target not currently curated in GtoImmuPdb

Target id: 1606

Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1

Family: M28: Aminopeptidase Y

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 750 11p11.12 FOLH1 folate hydrolase 1
Mouse 1 752 7 D3 Folh1 folate hydrolase 1
Rat 1 752 1q32 Folh1 folate hydrolase 1
Previous and Unofficial Names Click here for help
GCP2 | GCPII | NAALAD1 | PSM | glutamate carboxylase II | glutamate carboxypeptidase II | FGCP | folylpoly-gamma-glutamate carboxypeptidase | glutamate carboxypeptidase 2 | membrane glutamate carboxypeptidase | mGCP | NAALADase I | N-acetylated-alpha-linked acidic dipeptidase I | pteroylpoly-gamma-glutamate carboxypeptidase | prostate-specific membrane antigen | FOLH | folate hydrolase (prostate-specific membrane antigen) 1
Database Links Click here for help
Specialist databases
MEROPS M28.010 (Hs)
Other databases
Alphafold Q04609 (Hs), O35409 (Mm), P70627 (Rn)
BRENDA 3.4.17.21
CATH/Gene3D 1.20.930.40
ChEMBL Target CHEMBL1892 (Hs), CHEMBL5098 (Rn)
DrugBank Target Q04609 (Hs)
Ensembl Gene ENSG00000086205 (Hs), ENSMUSG00000001773 (Mm), ENSRNOG00000013770 (Rn)
Entrez Gene 2346 (Hs), 53320 (Mm), 85309 (Rn)
Human Protein Atlas ENSG00000086205 (Hs)
KEGG Enzyme 3.4.17.21
KEGG Gene hsa:2346 (Hs), mmu:53320 (Mm), rno:85309 (Rn)
OMIM 600934 (Hs)
Pharos Q04609 (Hs)
RefSeq Nucleotide NM_001193473 (Hs), NM_004476 (Hs), NM_001014986 (Hs), NM_001193471 (Hs), NM_001193472 (Hs), NM_001159706 (Mm), NM_016770 (Mm), NM_057185 (Rn)
RefSeq Protein NP_001180401 (Hs), NP_001180402 (Hs), NP_004467 (Hs), NP_001180400 (Hs), NP_001014986 (Hs), NP_058050 (Mm), NP_001153178 (Mm), NP_476533 (Rn)
UniProtKB Q04609 (Hs), O35409 (Mm), P70627 (Rn)
Wikipedia FOLH1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.21

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
vipivotide tetraxetan Small molecule or natural product Hs Inhibition 9.4 pKi 1
⤷ pKi 9.4 (Ki 3.7x10-10 M) [1]
Description: Inhibition of PSMA enzymatic activity
compound 8d [PMID: 15027864] Small molecule or natural product Primary target of this compound Hs Inhibition 8.5 pKi 2
⤷ pKi 8.5 (Ki 3x10-9 M) [2]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
capromab Peptide Approved drug Hs Binding - -
⤷

References

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1. Benešová M, Schäfer M, Bauder-Wüst U, Afshar-Oromieh A, Kratochwil C, Mier W, Haberkorn U, Kopka K, Eder M. (2015) Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer. J Nucl Med, 56 (6): 914-20. [PMID:25883127]

2. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem, 47 (7): 1729-38. [PMID:15027864]

How to cite this page

M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 02/05/2022. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606.