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Folate hydrolase (prostate-specific membrane antigen) 1

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Target not currently curated in GtoImmuPdb

Target id: 1606

Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1

Family: M28: Aminopeptidase Y

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 750 11p11.12 FOLH1 folate hydrolase 1
Mouse 1 752 7 D3 Folh1 folate hydrolase 1
Rat 1 752 1q32 Folh1 folate hydrolase 1
Previous and Unofficial Names Click here for help
GCP2 | GCPII | NAALAD1 | PSM | glutamate carboxylase II | glutamate carboxypeptidase II | FGCP | folylpoly-gamma-glutamate carboxypeptidase | glutamate carboxypeptidase 2 | membrane glutamate carboxypeptidase | mGCP | NAALADase I | N-acetylated-alpha-linked acidic dipeptidase I | pteroylpoly-gamma-glutamate carboxypeptidase | prostate-specific membrane antigen | FOLH | folate hydrolase (prostate-specific membrane antigen) 1
Database Links Click here for help
Specialist databases
MEROPS M28.010 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8d [PMID: 15027864] Small molecule or natural product Primary target of this compound Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
capromab Peptide Approved drug Hs Binding - -


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1. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem, 47 (7): 1729-38. [PMID:15027864]

How to cite this page

M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 27/10/2015. Accessed on 20/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY,