Caspase 6 | C14: Caspase | IUPHAR/BPS Guide to PHARMACOLOGY

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Caspase 6

Target not currently curated in GtoImmuPdb

Target id: 1622

Nomenclature: Caspase 6

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 293 4q25 CASP6 caspase 6
Mouse - 276 3 H1 Casp6 caspase 6
Rat - 277 2q43 Casp6 caspase 6
Previous and Unofficial Names
apoptotic protease Mch-2 | MCH2 | caspase 6, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.005 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Endogenous activators (Human)
Caspase 8, caspase 9, caspase 10, GrB

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Ac-VEID-CHO Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 8x10-9 M) [1]
Z-VEID-FMK Hs Inhibition - - 2
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0034097 response to cytokine ISO
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002525 acute inflammatory response to non-antigenic stimulus ISO


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1. Chu W, Rothfuss J, Chu Y, Zhou D, Mach RH. (2009) Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J. Med. Chem., 52 (8): 2188-91. [PMID:19326941]

2. Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH, Earnshaw WC. (2002) Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J., 21 (8): 1967-77. [PMID:11953316]

How to cite this page

C14: Caspase: Caspase 6. Last modified on 14/07/2015. Accessed on 10/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,