Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	293	4q25	CASP6	caspase 6
Mouse	-	276	3 G3	Casp6	caspase 6
Rat	-	277	2q43	Casp6	caspase 6

Previous and Unofficial Names

apoptotic protease Mch-2 | MCH2 | caspase 6, apoptosis-related cysteine peptidase

Database Links
Specialist databases
MEROPS	C14.005 (Hs)
Other databases
Alphafold	P55212 (Hs), O08738 (Mm), O35397 (Rn)
BRENDA	3.4.22.59
ChEMBL Target	CHEMBL3308 (Hs)
Ensembl Gene	ENSG00000138794 (Hs), ENSMUSG00000027997 (Mm), ENSRNOG00000052613 (Rn)
Entrez Gene	839 (Hs), 12368 (Mm), 83584 (Rn)
Human Protein Atlas	ENSG00000138794 (Hs)
KEGG Enzyme	3.4.22.59
KEGG Gene	hsa:839 (Hs), mmu:12368 (Mm), rno:83584 (Rn)
OMIM	601532 (Hs)
Pharos	P55212 (Hs)
RefSeq Nucleotide	NM_032992 (Hs), NM_001226 (Hs), NM_009811 (Mm), NM_031775 (Rn)
RefSeq Protein	NP_001217 (Hs), NP_116787 (Hs), NP_033941 (Mm), NP_113963 (Rn)
UniProtKB	P55212 (Hs), O08738 (Mm), O35397 (Rn)
Wikipedia	CASP6 (Hs)

Enzyme Reaction
EC Number: 3.4.22.59

Endogenous activators (Human)

Caspase 8, caspase 9, caspase 10, GrB

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference Ac-VEID-CHO Hs Inhibition 8.1 pIC50 1 ⤷ pIC50 8.1 (IC50 8x10-9 M) [1] Z-VEID-FMK Hs Inhibition - - 2 ⤷ [2]

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  Inflammation