Top ▲

Caspase 6

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1622

Nomenclature: Caspase 6

Family: C14: Caspase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 293 4q25 CASP6 caspase 6
Mouse - 276 3 G3 Casp6 caspase 6
Rat - 277 2q43 Casp6 caspase 6
Previous and Unofficial Names Click here for help
apoptotic protease Mch-2 | MCH2 | caspase 6, apoptosis-related cysteine peptidase
Database Links Click here for help
Specialist databases
MEROPS C14.005 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.59
Endogenous activators (Human)
Caspase 8, caspase 9, caspase 10, GrB

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Ac-VEID-CHO Small molecule or natural product Primary target of this compound Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 8x10-9 M) [1]
Z-VEID-FMK Peptide Hs Inhibition - - 2
[2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0034097 response to cytokine ISO
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002525 acute inflammatory response to non-antigenic stimulus ISO

References

Show »

1. Chu W, Rothfuss J, Chu Y, Zhou D, Mach RH. (2009) Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem, 52 (8): 2188-91. [PMID:19326941]

2. Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH, Earnshaw WC. (2002) Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J, 21 (8): 1967-77. [PMID:11953316]

How to cite this page

C14: Caspase: Caspase 6. Last modified on 14/07/2015. Accessed on 20/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1622.