Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	521	2q33.1	CASP10	caspase 10

Previous and Unofficial Names

apoptotic protease Mch-4 | FLICE2 | ICE-like apoptotic protease 4 | FAS-associated death domain protein interleukin-1B-converting enzyme 2 | MCH4 | caspase 10, apoptosis-related cysteine peptidase

Database Links
Specialist databases
MEROPS	C14.011 (Hs)
Other databases
Alphafold	Q92851 (Hs)
BRENDA	3.4.22.63
ChEMBL Target	CHEMBL5037 (Hs)
Ensembl Gene	ENSG00000003400 (Hs)
Entrez Gene	843 (Hs)
Human Protein Atlas	ENSG00000003400 (Hs)
KEGG Enzyme	3.4.22.63
KEGG Gene	hsa:843 (Hs)
OMIM	601762 (Hs)
Orphanet	ORPHA119179 (Hs)
Pharos	Q92851 (Hs)
RefSeq Nucleotide	NM_001206542 (Hs), NM_001206524 (Hs), NM_001230 (Hs), NM_032974 (Hs), NM_032976 (Hs), NM_032977 (Hs)
RefSeq Protein	NP_001193453 (Hs), NP_116758 (Hs), NP_116759 (Hs), NP_001221 (Hs), NP_001193471 (Hs), NP_116756 (Hs)
UniProtKB	Q92851 (Hs)
Wikipedia	CASP10 (Hs)

Enzyme Reaction
EC Number: 3.4.22.63

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference caspase 10 Hs - - pro-caspase 3 Hs - - pro-caspase 6 Hs - - pro-caspase 7 Hs - -

Endogenous activators (Human)

DISC

Clinically-Relevant Mutations and Pathophysiology
Disease:  Autoimmune lymphoproliferative syndrome, type IIA; ALPS2A Synonyms: Autoimmune lymphoproliferative syndrome [Orphanet: ORPHA3261] [Disease Ontology: DOID:6688] Disease Ontology: DOID:6688 OMIM: 603909 Orphanet: ORPHA3261
Disease:  Gastric cancer Synonyms: Stomach cancer Disease Ontology: DOID:10534 OMIM: 613659
Disease:  Lymphoma, non-hodgkin, familial Description: A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and lethargy. Synonyms: Non-Hodgkin lymphoma [Disease Ontology: DOID:0060060] Disease Ontology: DOID:0060060 OMIM: 605027