Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	242	19p13.12	CASP14	caspase 14
Mouse	-	257	10 C1	Casp14	caspase 14
Rat	-	246	7q11	Casp14	caspase 14

Previous and Unofficial Names

mini-ICE | MICE | caspase 14, apoptosis-related cysteine peptidase

Database Links
Specialist databases
MEROPS	C14.018 (Hs)
Other databases
Alphafold	P31944 (Hs), O89094 (Mm), D3ZZ65 (Rn)
BRENDA	3.4.22.-
ChEMBL Target	CHEMBL5991 (Hs)
Ensembl Gene	ENSG00000105141 (Hs), ENSMUSG00000005355 (Mm), ENSRNOG00000007352 (Rn)
Entrez Gene	23581 (Hs), 12365 (Mm), 299587 (Rn)
Human Protein Atlas	ENSG00000105141 (Hs)
KEGG Enzyme	3.4.22.-
KEGG Gene	hsa:23581 (Hs), mmu:12365 (Mm), rno:299587 (Rn)
OMIM	605848 (Hs)
Pharos	P31944 (Hs)
RefSeq Nucleotide	NM_012114 (Hs), NM_009809 (Mm), NM_001191776 (Rn)
RefSeq Protein	NP_036246 (Hs), NP_033939 (Mm), NP_001178705 (Rn)
UniProtKB	P31944 (Hs), O89094 (Mm), D3ZZ65 (Rn)
Wikipedia	CASP14 (Hs)

Enzyme Reaction
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference grassystatin A Hs Inhibition 5.3 pIC50 1 ⤷ pIC50 5.3 (IC50 5x10-6 M) [1]