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Caspase 14

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Target not currently curated in GtoImmuPdb

Target id: 1627

Nomenclature: Caspase 14

Family: C14: Caspase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 242 19p13.12 CASP14 caspase 14
Mouse - 257 10 C1 Casp14 caspase 14
Rat - 246 7q11 Casp14 caspase 14
Previous and Unofficial Names Click here for help
mini-ICE | MICE | caspase 14, apoptosis-related cysteine peptidase
Database Links Click here for help
Specialist databases
MEROPS C14.018 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
grassystatin A Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 5x10-6 M) [1]

References

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1. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem, 52 (18): 5732-47. [PMID:19715320]

How to cite this page

C14: Caspase: Caspase 14. Last modified on 29/07/2015. Accessed on 06/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1627.