Caspase 14 | C14: Caspase | IUPHAR/BPS Guide to PHARMACOLOGY

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Caspase 14

Target not currently curated in GtoImmuPdb

Target id: 1627

Nomenclature: Caspase 14

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 242 19p13.1 CASP14 caspase 14
Mouse - 257 10 C1 Casp14 caspase 14
Rat - 246 7q11 Casp14 caspase 14
Previous and Unofficial Names
mini-ICE | MICE | caspase 14, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.018 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
grassystatin A Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 5x10-6 M) [1]


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1. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J. Med. Chem., 52 (18): 5732-47. [PMID:19715320]

How to cite this page

C14: Caspase: Caspase 14. Last modified on 29/07/2015. Accessed on 17/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY,