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MMP16

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Target not currently curated in GtoImmuPdb

Target id: 1640

Nomenclature: MMP16

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 607 8q21.3 MMP16 matrix metallopeptidase 16
Mouse 1 607 4 7.08 cM Mmp16 matrix metallopeptidase 16
Rat 1 607 5q13 Mmp16 matrix metallopeptidase 16
Previous and Unofficial Names Click here for help
MMP- X2 | membrane-type matrix metalloproteinase 3 | MT3MMP | MTMMP3 | Membrane type 3-MMP | matrix metallopeptidase 16 (membrane-inserted)
Database Links Click here for help
Specialist databases
MEROPS M10.016 (Hs)
Other databases
Alphafold P51512 (Hs), Q9WTR0 (Mm), O35548 (Rn)
BRENDA 3.4.24.-
CATH/Gene3D 2.110.10.10, 3.40.390.10
ChEMBL Target CHEMBL2200 (Hs)
DrugBank Target P51512 (Hs)
Ensembl Gene ENSG00000156103 (Hs), ENSMUSG00000028226 (Mm), ENSRNOG00000005708 (Rn)
Entrez Gene 4325 (Hs), 17389 (Mm), 65205 (Rn)
Human Protein Atlas ENSG00000156103 (Hs)
KEGG Enzyme 3.4.24.-
KEGG Gene hsa:4325 (Hs), mmu:17389 (Mm), rno:65205 (Rn)
OMIM 602262 (Hs)
Pharos P51512 (Hs)
RefSeq Nucleotide NM_005941 (Hs), NM_019724 (Mm), NM_080776 (Rn)
RefSeq Protein NP_005932 (Hs), NP_062698 (Mm), NP_542954 (Rn)
UniProtKB P51512 (Hs), Q9WTR0 (Mm), O35548 (Rn)
Wikipedia MMP16 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SL422 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.5 pKi 2
⤷ pKi 7.5 (Ki 3.5x10-8 M) [2]
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.1 pIC50 1
⤷ pIC50 8.1 (IC50 8x10-9 M) [1]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [2].

References

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1. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett, 14 (1): 47-50. [PMID:14684295]

2. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem, 44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP16. Last modified on 16/03/2017. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1640.