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MMP17

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Target not currently curated in GtoImmuPdb

Target id: 1641

Nomenclature: MMP17

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 603 12q24.33 MMP17 matrix metallopeptidase 17
Mouse - 578 5 68.18 cM Mmp17 matrix metallopeptidase 17
Rat - 587 12q13 Mmp17 matrix metallopeptidase 17
Previous and Unofficial Names Click here for help
MT4-MMP | membrane type-4 matrix metalloproteinase | matrix metallopeptidase 17 (membrane-inserted)
Database Links Click here for help
Specialist databases
MEROPS M10.017 (Hs)
Other databases
Alphafold Q9ULZ9 (Hs), Q9R0S3 (Mm), D3ZXJ0 (Rn)
BRENDA 3.4.24.-
CATH/Gene3D 2.110.10.10, 3.40.390.10
ChEMBL Target CHEMBL2937 (Hs)
DrugBank Target Q9ULZ9 (Hs)
Ensembl Gene ENSG00000198598 (Hs), ENSMUSG00000029436 (Mm), ENSRNOG00000023643 (Rn)
Entrez Gene 4326 (Hs), 23948 (Mm), 288626 (Rn)
Human Protein Atlas ENSG00000198598 (Hs)
KEGG Enzyme 3.4.24.-
KEGG Gene hsa:4326 (Hs), mmu:23948 (Mm), rno:288626 (Rn)
OMIM 602285 (Hs)
Pharos Q9ULZ9 (Hs)
RefSeq Nucleotide NM_016155 (Hs), NM_011846 (Mm), NM_001105925 (Rn)
RefSeq Protein NP_057239 (Hs), NP_035976 (Mm), NP_001099395 (Rn)
UniProtKB Q9ULZ9 (Hs), Q9R0S3 (Mm), D3ZXJ0 (Rn)
Wikipedia MMP17 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.5 pIC50 1
⤷ pIC50 8.5 (IC50 3.4x10-9 M) [1]

References

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1. Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C et al.. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J Biol Chem, 282 (38): 27781-91. [PMID:17623656]

How to cite this page

M10: Matrix metallopeptidase: MMP17. Last modified on 16/03/2017. Accessed on 03/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1641.