<i>P2RY10</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

P2RY10

Target not currently curated in GtoImmuPdb

Target id: 165

Nomenclature: P2RY10

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 339 Xq21.1 P2RY10 P2Y receptor family member 10
Mouse 7 328 X D P2ry10 purinergic receptor P2Y, G-protein coupled 10
Rat 7 388 Xq31 P2ry10 P2Y receptor family member 10
Previous and Unofficial Names
purinergic receptor P2Y10 | purinergic receptor P2Y, G-protein coupled 10 | purinergic receptor P2Y
Database Links
Specialist databases
GPCRDB p2y10_human (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
LPA
sphingosine 1-phosphate
Comments: Proposed ligands, single publication

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
sphingosine 1-phosphate Hs Agonist 7.3 pEC50 2
pEC50 7.3 [2]
LPA Hs Agonist 6.9 pEC50 2
pEC50 6.9 [2]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
dioctanoylglycerol pyrophosphate Hs Antagonist - - 2
[2]
JTE-013 Hs Antagonist - - 2
[2]
Tissue Distribution
Platelets
Expression level:  High
Species:  Human
Technique:  qRT-PCR (microarray analysis) and western blotting
References:  1
B-cells
Expression level:  High
Species:  Mouse
Technique:  Northern blot, subtractive hybridisation
References:  3
Placenta, uterus, prostate, brain, lung, and skeletal muscle
Expression level:  High
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  N3H
Global MAF (%):  19
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 7|24|49|1
Minor allele count:  C=0.187/311
SNP accession: 
Validation:  1000 Genomes, HapMap

References

Show »

1. Amisten S, Braun OO, Bengtsson A, Erlinge D. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. Thromb. Res., 122 (1): 47-57. [PMID:17920662]

2. Murakami M, Shiraishi A, Tabata K, Fujita N. (2008) Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun., 371 (4): 707-12. [PMID:18466763]

3. Rao S, Garrett-Sinha LA, Yoon J, Simon MC. (1999) The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J. Biol. Chem., 274 (48): 34245-52. [PMID:10567398]

Contributors

Show »

How to cite this page

Select citation format: