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ADAM12

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Target not currently curated in GtoImmuPdb

Target id: 1660

Nomenclature: ADAM12

Family: M12: Astacin/Adamalysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 909 10q26.2 ADAM12 ADAM metallopeptidase domain 12
Mouse 1 903 7 F3 Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Rat - - 1q41 Adam12 ADAM metallopeptidase domain 12
Previous and Unofficial Names Click here for help
MCMPMltna | MLTN
Database Links Click here for help
Specialist databases
MEROPS M12.212 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 5.93x10-9 M) [1]
Description: Measured in a cell-based assay.

References

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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg Med Chem Lett, 14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM12. Last modified on 29/07/2015. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1660.