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Target not currently curated in GtoImmuPdb

Target id: 168

Nomenclature: TAAR3

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor: thought to be a pseudogene in man though functional in rodents
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 343 6q23.2 TAAR3P trace amine associated receptor 3, pseudogene 1
Mouse 7 343 10 A4 Taar3 trace amine-associated receptor 3
Rat 7 342 1p12 Taar3 trace amine-associated receptor 3
Previous and Unofficial Names Click here for help
GPR57 | G protein-coupled receptor 57 | trace amine receptor 3 | TAAR3 | trace amine associated receptor 3 (gene/pseudogene)
Database Links Click here for help
Specialist databases
GPCRdb taar3_human (Hs), taar3_mouse (Mm), taar3_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands Click here for help
Comments: probable pseudogene.

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
isoamylamine Small molecule or natural product Ligand is endogenous in the given species Ligand has a PDB structure Mm Full agonist 5.0 pEC50 2
pEC50 5.0 (EC50 1x10-5 M) [2]
Agonist Comments
Cyclohexylamine has been shown to be an agonist at this receptor in mice [2]. It has been shown that the agonists of murine TAAR3 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution Click here for help
Olfactory epithelium
Species:  Mouse
Technique:  In situ hybridisation and RT-PCR.
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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1. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta, 1490 (3): 311-23. [PMID:10684976]

2. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]


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