<i>TAAR4P </i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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TAAR4P

Target not currently curated in GtoImmuPdb

Target id: 169

Nomenclature: TAAR4P

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor: pseudogene in man but functional in rodents
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 6q23.2 TAAR4P trace amine associated receptor 4, pseudogene
Mouse 7 347 10 A4 Taar4 trace amine-associated receptor 4
Rat 7 347 1p12 Taar4 trace amine-associated receptor 4
Previous and Unofficial Names
trace amine receptor 4 | trace amine-associated receptor 4
Database Links
Specialist databases
GPCRDB taar4_mouse (Mm), taar4_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
β-phenylethylamine Mm Agonist 6.0 pEC50 1
pEC50 6.0 (EC50 1x10-6 M) [1]
xylometazoline Mm Full agonist - - 3
[3]
β-phenylethylamine Rn Partial agonist - - 3
[3]
naphazoline Mm Agonist - - 3
[3]
naphazoline Rn Partial agonist - - 3
[3]
View species-specific agonist tables
Agonist Comments
Agonist activity for β-phenylethylamine, naphazoline and xylometazoline was measured by CRE-SEAP reporter gene assay [3].
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  3
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
The compound β-phenylethylamine is elevated in urine in stress responses in rodents and humans, suggesting a role for TAAR4 in stress and social cues [1-2].

References

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1. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

2. Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP. (2009) International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev., 61 (1): 1-8. [PMID:19325074]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

Contributors

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