Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	337	6q23.2	TAAR5	trace amine associated receptor 5	4
Mouse	7	337	10 A4	Taar5	trace amine-associated receptor 5
Rat	7	337	1p12	Taar5	trace amine-associated receptor 5

Previous and Unofficial Names

PNR | Trace amine receptor 5

Database Links
Specialist databases
GPCRdb	taar5_human (Hs), taar5_mouse (Mm), taar5_rat (Rn)
Other databases
Alphafold	O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
ChEMBL Target	CHEMBL3714046 (Hs), CHEMBL3784908 (Mm)
Ensembl Gene	ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
Entrez Gene	9038 (Hs), 215854 (Mm), 294123 (Rn)
Human Protein Atlas	ENSG00000135569 (Hs)
KEGG Gene	hsa:9038 (Hs), mmu:215854 (Mm), rno:294123 (Rn)
OMIM	607405 (Hs)
Pharos	O14804 (Hs)
RefSeq Nucleotide	NM_003967 (Hs), NM_001009574 (Mm), NM_001009650 (Rn)
RefSeq Protein	NP_003958 (Hs), NP_001009574 (Mm), NP_001009650 (Rn)
UniProtKB	O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
Wikipedia	TAAR5 (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference trimethylamine Mm Full agonist 6.5 pEC50 2 ⤷ pEC50 6.5 (EC50 3x10-7 M) [2] dimethylethylamine Mm Full agonist 6.2 pEC50 5 ⤷ pEC50 6.2 (EC50 7x10-7 M) [5]
Agonist Comments
It is reported that mTAAR5 responded to N-methylpiperidine [2]. Staubert et al. show that the agonists of murine TAAR5 do not activate intact primate and mammalian orthologs [3].

Tissue Distribution
Skeletal muscle, amydgala, hippocampus, caudate nucleus, thalamus, hypothalamus, substantia nigra. Species:  Human Technique:  Northern blot References:  4
Grueneberg ganglion (nasal septum, nasal cavity and nasal roof) Species:  Mouse Technique:  RT-PCR and in situ hybridisation References:  1
Olfactory epithelium Species:  Mouse Technique:  RT-PCR References:  2
Tissue Distribution Comments
No transcripts of TAAR5 were detected by Northern blot analysis in corpus callosum, subthalamic nucleus, lung, heart, pancreas, adult liver, lymph node, bone marrow, thymus, placenta, spleen and fetal liver [4].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  R330C Global MAF (%):  2 Subpopulation MAF (%):  AFR|AMR: 10|1 Minor allele count:  A=0.024/52 SNP accession:  VAR_055924, rs35839363 Validation:  1000 Genomes, Frequency, Cluster
Type:  Naturally occurring SNP Species:  Human Amino acid change:  T272M Comment on frequency:  Low frequency (<10% in tested population) SNP accession:  rs34746740