Top ▲

TAAR8

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 172

Nomenclature: TAAR8

Family: Class A Orphans

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 342 6q23.2 TAAR8 trace amine associated receptor 8 3
Mouse 7 344 10 A4 Taar8b trace amine-associated receptor 8B
Rat 7 344 1p12 Taar8a trace amine associated receptor 8A
Previous and Unofficial Names Click here for help
GPR102 | TAR11 | TAR5 | trace amine receptor 5 | trace amine receptor 11 | trace amine receptor 8a | trace amine associated receptor 8
Database Links Click here for help
Specialist databases
GPCRDB taar8_human (Hs), taa8b_mouse (Mm), taa8a_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution Click here for help
Kidney and amygdala
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  4
Intestine, spleen, testis
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets Click here for help

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  D328A
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|4|2|7
Minor allele count:  C=0.049/106
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S153N
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  A=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency

References

Show »

1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. U.S.A., 98 (16): 8966-71. [PMID:11459929]

2. Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R. (2012) Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors. J. Endocrinol., 213 (3): 223-30. [PMID:22442117]

3. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275 (1): 83-91. [PMID:11574155]

4. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

Contributors

Show »

How to cite this page