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TAAR8

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Target not currently curated in GtoImmuPdb

Target id: 172

Nomenclature: TAAR8

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 342 6q23.2 TAAR8 trace amine associated receptor 8 3
Mouse 7 344 10 A4 Taar8b trace amine-associated receptor 8B
Rat 7 344 1p12 Taar8a trace amine associated receptor 8A
Previous and Unofficial Names Click here for help
GPR102 | TAR11 | TAR5 | trace amine receptor 5 | trace amine receptor 11 | trace amine receptor 8a | trace amine associated receptor 8
Database Links Click here for help
Specialist databases
GPCRdb taar8_human (Hs), taa8b_mouse (Mm), taa8a_rat (Rn)
Other databases
Alphafold Q969N4 (Hs), Q5QD06 (Mm), Q923X9 (Rn)
ChEMBL Target CHEMBL4523902 (Hs)
Ensembl Gene ENSG00000146385 (Hs), ENSMUSG00000100186 (Mm), ENSRNOG00000070320 (Rn)
Entrez Gene 83551 (Hs), 382348 (Mm), 319104 (Rn)
Human Protein Atlas ENSG00000146385 (Hs)
KEGG Gene hsa:83551 (Hs), mmu:382348 (Mm), rno:319104 (Rn)
OMIM 606927 (Hs)
Pharos Q969N4 (Hs)
RefSeq Nucleotide NM_053278 (Hs), NM_001010837 (Mm), NM_175599 (Rn)
RefSeq Protein NP_444508 (Hs), NP_001010837 (Mm), NP_783189 (Rn)
UniProtKB Q969N4 (Hs), Q5QD06 (Mm), Q923X9 (Rn)
Wikipedia TAAR8 (Hs)
Tissue Distribution Click here for help
Kidney and amygdala
Species:  Human
Technique:  RT-PCR
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  4
Intestine, spleen, testis
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  D328A
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|4|2|7
Minor allele count:  C=0.049/106
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs8192627
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S153N
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  A=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs8192626
Validation:  1000 Genomes, HapMap, Frequency

References

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1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA, 98 (16): 8966-71. [PMID:11459929]

2. Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R. (2012) Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors. J Endocrinol, 213 (3): 223-30. [PMID:22442117]

3. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275 (1): 83-91. [PMID:11574155]

4. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

Contributors

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