Quaternary Structure: Complexes

Interferon-γ receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	489	6q23.3	IFNGR1	interferon gamma receptor 1
Mouse	1	477	10 8.49 cM	Ifngr1	interferon gamma receptor 1
Rat	-	-		Ifngr1	interferon gamma receptor 1

Previous and Unofficial Names

CD119 | interferon gamma receptor | Ifgr | IFN-gammaR | Nktar

Database Links
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364171 (Hs)
DrugBank Target	P15260 (Hs)
Ensembl Gene	ENSG00000027697 (Hs), ENSMUSG00000020009 (Mm), ENSRNOG00000012074 (Rn)
Entrez Gene	3459 (Hs), 15979 (Mm), 116465 (Rn)
Human Protein Atlas	ENSG00000027697 (Hs)
KEGG Gene	hsa:3459 (Hs), mmu:15979 (Mm), rno:116465 (Rn)
OMIM	107470 (Hs)
Pharos	P15260 (Hs)
UniProtKB	P15260 (Hs), P15261 (Mm)
Wikipedia	IFNGR1 (Hs)

Immunopharmacology Comments

A subunit of the functional receptor for interferon γ.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0001774 microglial cell activation ISS GO:0004906 interferon-gamma receptor activity TAS GO:0048143 astrocyte activation ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 6 GO processes GO:0004896 cytokine receptor activity IBA GO:0004906 interferon-gamma receptor activity TAS GO:0019221 cytokine-mediated signaling pathway IBA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:1904469 positive regulation of tumor necrosis factor secretion ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0001774 microglial cell activation ISS