Quaternary Structure: Complexes

Interferon-γ receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	489	6q23.3	IFNGR1	interferon gamma receptor 1
Mouse	1	477	10 8.49 cM	Ifngr1	interferon gamma receptor 1
Rat	-	-		Ifngr1	interferon gamma receptor 1

Previous and Unofficial Names

CD119 | interferon gamma receptor | Ifgr | IFN-gammaR | Nktar

Database Links
Alphafold	P15260 (Hs), P15261 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364171 (Hs)
DrugBank Target	P15260 (Hs)
Ensembl Gene	ENSG00000027697 (Hs), ENSMUSG00000020009 (Mm), ENSRNOG00000012074 (Rn)
Entrez Gene	3459 (Hs), 15979 (Mm), 116465 (Rn)
Human Protein Atlas	ENSG00000027697 (Hs)
KEGG Gene	hsa:3459 (Hs), mmu:15979 (Mm), rno:116465 (Rn)
OMIM	107470 (Hs)
Pharos	P15260 (Hs)
UniProtKB	P15260 (Hs), P15261 (Mm)
Wikipedia	IFNGR1 (Hs)

Immunopharmacology Comments

A subunit of the functional receptor for interferon γ.

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0001774 microglial cell activation ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 6 GO processes GO:0004896 cytokine receptor activity IBA GO:0004906 type II interferon receptor activity IDA GO:0019221 cytokine-mediated signaling pathway IBA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0038196 type III interferon-mediated signaling pathway IDA GO:0060333 type II interferon-mediated signaling pathway IDA

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0001774 microglial cell activation ISS GO:0004906 type II interferon receptor activity IDA GO:0038196 type III interferon-mediated signaling pathway IDA GO:0048143 astrocyte activation ISS GO:0060333 type II interferon-mediated signaling pathway IDA