<i>TAAR9</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

TAAR9

Target not currently curated in GtoImmuPdb

Target id: 173

Nomenclature: TAAR9

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor: pseudogene in some individuals
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 348 6q23.2 TAAR9 trace amine associated receptor 9 (gene/pseudogene)
Mouse 7 348 10 A4 Taar9 trace amine-associated receptor 9
Rat 7 338 1p12 Taar9 trace amine-associated receptor 9
Previous and Unofficial Names
TRAR3 | trace amine receptor 3 | trace amine receptor 9
Database Links
Specialist databases
GPCRDB taar9_human (Hs), taar9_mouse (Mm), taar9_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Kidney
Species:  Human
Technique:  RT-PCR
References:  1
Pituitary gland, skeletal muscle
Species:  Human
Technique:  Northern blot
References:  4
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  3
Tissue Distribution Comments
No expression of TAAR9 was detected by RT-PCR in the Grueneberg ganglion [2]. TAAR9 expression was not detected by Northern blot analysis in thalamus, amygdala, midbrain, hippocampus, putamen, caudate, frontal cortex, pons, prostate, stomach, heart, bladder, small intestine, colon or uterus [4].
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A278T
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 1|4|2|5
Minor allele count:  A=0.032/69
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S335L
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 11|1
Minor allele count:  T=0.028/60
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
General Comments
TAAR9 appears to be functional in most individuals but has a polymorphic premature stop codon at amino acid 61 (rs2842899) with an allele frequency of 10–30% in different populations [4].

References

Show »

1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. U.S.A., 98 (16): 8966-71. [PMID:11459929]

2. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

3. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

4. Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF. (2003) Discovery of a null mutation in a human trace amine receptor gene. Genomics, 82: 531-536. [PMID:14559210]

Contributors

Show »

How to cite this page

Select citation format: