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Interleukin 22 receptor, α1 subunit

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1731

Nomenclature: Interleukin 22 receptor, α1 subunit

Family: IL-10 receptor family

Quaternary Structure: Complexes
Interleukin-22α1/20β heteromer
Interleukin-22α1/10β heteromer
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 574 1p36.11 IL22RA1 interleukin 22 receptor subunit alpha 1
Mouse 1 581 4 67.99 cM Il22ra1 interleukin 22 receptor, alpha 1
Rat - - Il22ra1 interleukin 22 receptor subunit alpha 1
Previous and Unofficial Names Click here for help
CRF2-9 | IL22R | interleukin-22 receptor subunit alpha-1 | interleukin 22 receptor, alpha 1
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
IL22RA1 is a subunit in the heterodimeric receptors for interleukins 20 and 24 (which bind to the interleukin-22α1/20β heteromer) and IL-22 (which binds to the interleukin-22α1/10β heteromer).
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0004904 interferon receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0042018 interleukin-22 receptor activity ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050728 negative regulation of inflammatory response ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050728 negative regulation of inflammatory response ISS

How to cite this page

IL-10 receptor family: Interleukin 22 receptor, α1 subunit. Last modified on 06/04/2017. Accessed on 07/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1731.