Top ▲

NLRP7

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1774

Nomenclature: NLRP7

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 980 19q13.42 NLRP7 NLR family pyrin domain containing 7
Previous and Unofficial Names Click here for help
CLR19.4 | NALP7 | NOD12 | PAN7 | PYPAF3 | NACHT, leucine rich repeat and PYD containing 7 | XXbac-BCX195L8.11-001 | HYDM | NLR family, pyrin domain containing 7
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP7 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0071347 cellular response to interleukin-1 IEP
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Physiological Functions Comments
Involved in embyronic development and regulation of interleukin 1β.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Abnormal pregnancies
Disease:  Complete hydatidiform mole
Synonyms: Hydatidiform mole, recurrent, 1; HYDM1 [OMIM: 231090]
OMIM: 231090
Orphanet: ORPHA254688
Disease:  Endometrial cancer
Disease Ontology: DOID:1380
OMIM: 608089
Disease:  Partial hydatidiform mole
Synonyms: Hydatidiform mole, recurrent, 1; HYDM1 [OMIM: 231090]
OMIM: 231090
Orphanet: ORPHA254693
Disease:  Testicular cancer
Disease Ontology: DOID:2998

Contributors

Show »

How to cite this page