NLRP7 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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NLRP7

target has curated data in GtoImmuPdb

Target id: 1774

Nomenclature: NLRP7

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 980 19q13.42 NLRP7 NLR family pyrin domain containing 7
Previous and Unofficial Names
CLR19.4 | NALP7 | NOD12 | PAN7 | PYPAF3 | NACHT, leucine rich repeat and PYD containing 7 | XXbac-BCX195L8.11-001 | HYDM | NLR family, pyrin domain containing 7
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP7 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0050713 negative regulation of interleukin-1 beta secretion IMP
GO:0050718 positive regulation of interleukin-1 beta secretion IBA
GO:0071347 cellular response to interleukin-1 IEP
GO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
Physiological Functions Comments
Involved in embyronic development and regulation of interleukin 1β.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Abnormal pregnancies
Disease:  Complete hydatidiform mole
Synonyms: Hydatidiform mole, recurrent, 1; HYDM1 [OMIM: 231090]
OMIM: 231090
Orphanet: ORPHA254688
Disease:  Endometrial cancer
Disease Ontology: DOID:1380
OMIM: 608089
Disease:  Partial hydatidiform mole
Synonyms: Hydatidiform mole, recurrent, 1; HYDM1 [OMIM: 231090]
OMIM: 231090
Orphanet: ORPHA254693
Disease:  Testicular cancer
Disease Ontology: DOID:2998

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
NOD-like receptor family: NLRP7. Last modified on 22/03/2017. Accessed on 21/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1774.