NLRP12 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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NLRP12

Target not currently curated in GtoImmuPdb

Target id: 1779

Nomenclature: NLRP12

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1061 19q13.42 NLRP12 NLR family pyrin domain containing 12
Mouse - 1054 7 1.88 cM Nlrp12 NLR family, pyrin domain containing 12
Rat - - 1q12 Nlrp12 NLR family, pyrin domain containing 12
Previous and Unofficial Names
CLR19.3 | NALP12 | PAN6 | PYPAF7 | RNO2 | NACHT, leucine rich repeat and PYD containing 12 | RNO | Monarch1 | FCAS2 | NLR family, pyrin domain containing 12 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Physiological Functions Comments
Involved in inflammasome formation, bacterial control and inflammatory migration.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Dermatitis
Description: Includes atopic, seborrhoeic, and contact dermatitis.
Disease Ontology: DOID:2723
Disease:  Familial cold autoinflammatory syndrome 2; FCAS2
Synonyms: NLRP12-associated hereditary periodic fever syndrome [Orphanet: ORPHA247868]
OMIM: 611762
Orphanet: ORPHA247868

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