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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 2923 | 1p13.3 | CELSR2 | cadherin EGF LAG seven-pass G-type receptor 2 | 8 |
| Mouse | 7 | 2919 | 3 47.02 cM | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 17 |
| Rat | 7 | 2144 | 2q34 | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | |
| Previous and Unofficial Names |
| ADGRC2 (adhesion G protein-coupled receptor C2) | MEGF3 | multiple epidermal growth factor-like domains 3 |
| Database Links |
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| Specialist databases | |
| GPCRdb | celr2_human (Hs), celr2_mouse (Mm), celr2_rat (Rn) |
| Other databases | |
| Alphafold | Q9HCU4 (Hs), Q9R0M0 (Mm), Q9QYP2 (Rn) |
| Ensembl Gene | ENSG00000143126 (Hs), ENSMUSG00000068740 (Mm), ENSRNOG00000020058 (Rn) |
| Entrez Gene | 1952 (Hs), 53883 (Mm), 83465 (Rn) |
| Human Protein Atlas | ENSG00000143126 (Hs) |
| KEGG Gene | hsa:1952 (Hs), mmu:53883 (Mm), rno:83465 (Rn) |
| OMIM | 604265 (Hs) |
| Pharos | Q9HCU4 (Hs) |
| RefSeq Nucleotide | NM_001408 (Hs), NM_017392 (Mm), NM_001191110 (Rn) |
| RefSeq Protein | NP_001399 (Hs), NP_059088 (Mm), NP_001178039 (Rn) |
| UniProtKB | Q9HCU4 (Hs), Q9R0M0 (Mm), Q9QYP2 (Rn) |
| Wikipedia | CELSR2 (Hs) |
| Associated Protein Comments | ||
| Extracellular and transmembrane interactors: ADGRC2 [11]. |
| Agonist Comments | ||
| No ligands identified: orphan receptor. |
| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Other - See Comments | |
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Comments:
Principal transduction is potentially through Gαq/11 by calcium imaging [11]. Correlation with CamKII activity [11], correlation with Jun Kinase activity [4], increases in intracellular calcium levels associated with Celsr2 and Frizzled-8-positive haemopoetic stem cells under stress (5FU incubation) [14]. |
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| References: | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||
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| General Comments |
| CELSR2 (cadherin, EGF LAG seven-pass G-type receptor 2) is a receptor that belongs to Family IV Adhesion-GPCRs together with CELSR2 and CELSR3 [7]. Family IV Adhesion-GPCRs have orthologs in vertebrate and invertebrate species. |
1. Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, Li L. (2003) Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood, 101 (2): 383-9. [PMID:12393558]
2. Beall SA, Boekelheide K, Johnson KJ. (2005) Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. J Androl, 26 (4): 529-38. [PMID:15955893]
3. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. (2007) Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene, 387 (1-2): 38-48. [PMID:17056209]
4. Cortijo C, Gouzi M, Tissir F, Grapin-Botton A. (2012) Planar cell polarity controls pancreatic Beta cell differentiation and glucose homeostasis. Cell Rep, 2 (6): 1593-606. [PMID:23177622]
5. Formstone CJ, Barclay J, Rees M, Little PF. (2000) Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9. Mamm Genome, 11 (5): 392-4. [PMID:10790539]
6. Formstone CJ, Little PF. (2001) The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev, 109: 91-94. [PMID:11677057]
7. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]
8. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N. (1996) Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res, 3 (5): 321-9, 341-54. [PMID:9039502]
9. Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci, 30 (28): 9392-401. [PMID:20631168]
10. Shima Y, Copeland NG, Gilbert DJ, Jenkins NA, Chisaka O, Takeichi M, Uemura T. (2002) Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. Dev Dyn, 223 (3): 321-32. [PMID:11891983]
11. Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T. (2007) Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Nat Neurosci, 10 (8): 963-9. [PMID:17618280]
12. Shima Y, Kengaku M, Hirano T, Takeichi M, Uemura T. (2004) Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell, 7 (2): 205-16. [PMID:15296717]
13. Stevens CF, Williams JH. (2000) "Kiss and run" exocytosis at hippocampal synapses. Proc Natl Acad Sci USA, 97 (23): 12828-33. [PMID:11050187]
14. Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T et al.. (2012) Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell, 150 (2): 351-65. [PMID:22817897]
15. Tissir F, Goffinet AM. (2006) Expression of planar cell polarity genes during development of the mouse CNS. Eur J Neurosci, 23 (3): 597-607. [PMID:16487141]
16. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci, 13 (6): 700-7. [PMID:20473291]
17. Usui T, Shima Y, Shimada Y, Hirano S, Burgess RW, Schwarz TL, Takeichi M, Uemura T. (1999) Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell, 98 (5): 585-95. [PMID:10490098]
