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Adhesion Class GPCRs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [1] containing a GPCR proteolytic site. The N-terminus often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [13,47]. Several receptors have been suggested to function as mechanosensors [6,30,33,44]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [15].

Receptors

ADGRA1 C Show summary » More detailed page

ADGRA2 C Show summary » More detailed page

ADGRA3 C Show summary » More detailed page

ADGRB1 C Show summary » More detailed page

ADGRB2 C Show summary » More detailed page

ADGRB3 C Show summary » More detailed page

CELSR1 C Show summary » More detailed page

CELSR2 C Show summary » More detailed page

CELSR3 C Show summary » More detailed page

ADGRD1 C Show summary » More detailed page

ADGRD2 C Show summary » More detailed page

ADGRE1 C Show summary » More detailed page

ADGRE2 C Show summary » More detailed page

ADGRE3 C Show summary » More detailed page

ADGRE4P C Show summary » More detailed page

ADGRE5 C Show summary » More detailed page

ADGRF1 C Show summary » More detailed page

ADGRF2 C Show summary » More detailed page

ADGRF3 C Show summary » More detailed page

ADGRF4 C Show summary » More detailed page

ADGRF5 C Show summary » More detailed page

ADGRG1 C Show summary » More detailed page

ADGRG2 C Show summary » More detailed page

ADGRG3 C Show summary » More detailed page

ADGRG4 C Show summary » More detailed page

ADGRG5 C Show summary » More detailed page

ADGRG6 C Show summary » More detailed page

ADGRG7 C Show summary » More detailed page

ADGRL1 C Show summary » More detailed page

ADGRL2 C Show summary » More detailed page

ADGRL3 C Show summary » More detailed page

ADGRL4 C Show summary » More detailed page

ADGRV1 C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.