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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 528 | 16q21 | ADGRG5 | adhesion G protein-coupled receptor G5 | |
| Mouse | 7 | 524 | 8 C5 | Adgrg5 | adhesion G protein-coupled receptor G5 | |
| Rat | 7 | 523 | 19p13 | Adgrg5 | adhesion G protein-coupled receptor G5 | |
| Previous and Unofficial Names |
| Gm1109 | GPR114 (G protein-coupled receptor 114) | PGR27 | UNQ2524/PRO6017 |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrg5_human (Hs), agrg5_mouse (Mm) |
| Other databases | |
| Alphafold | Q8IZF4 (Hs), Q3V3Z3 (Mm) |
| ChEMBL Target | CHEMBL4523890 (Hs) |
| Ensembl Gene | ENSG00000159618 (Hs), ENSMUSG00000061577 (Mm), ENSRNOG00000039891 (Rn) |
| Entrez Gene | 221188 (Hs), 382045 (Mm), 307645 (Rn) |
| Human Protein Atlas | ENSG00000159618 (Hs) |
| KEGG Gene | hsa:221188 (Hs), mmu:382045 (Mm), rno:307645 (Rn) |
| Pharos | Q8IZF4 (Hs) |
| RefSeq Nucleotide | NM_153837 (Hs), NM_001033468 (Mm), NM_001107410 (Mm) |
| RefSeq Protein | NP_722579 (Hs), NP_001028640 (Mm), NP_001100880 (Rn) |
| UniProtKB | Q8IZF4 (Hs), Q3V3Z3 (Mm) |
| Wikipedia | ADGRG5 (Hs) |
| Endogenous agonists |
| Peptides derived from the Stachel sequence: TYFAVLMQLSGDPVPAEL [8-9] |
| Agonist Comments | ||
| Peptides derived from the Stachel sequence: TYFAVLMQLSGDPVPAEL [8-9]. |
| Antagonist Comments | ||
| Dihydromunduletone, a rotenoid derivative, is an antagonist at ADGRG5 [8]. |
| Cell Type Associations | ||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gs family | |
| References: 5,8-9 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| General Comments |
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ADGRG5 (formerly GPR114) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1-4, 6 and 7 [3]. The genes of ADGRG1, ADGRG3 and ADGRG5 are syntenically clustered on human chromosome 16 and mouse chromosome 8 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [7]. Adgrg5 is mechano-sensitive and has two splice variants in mouse which significantly differ in their Gs-mediated basal activity [9]. Full coding sequence human cDNA is publicly available, IMAGE:5210813 [6], in mammalian expression vector pCMV-SPORT6. Original human gene prediction, AY140956 [4] incorrectly predicts the 3' end of the gene resulting in a longer protein, (Swiss-Prot ID: Q8IZF4, 570 aa), than the observed cDNAs. |
1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
2. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. (2007) Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene, 387 (1-2): 38-48. [PMID:17056209]
3. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]
4. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]
5. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. (2012) Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett, 586 (8): 1214-9. [PMID:22575658]
6. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]
7. Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J. (2011) Specific expression of GPR56 by human cytotoxic lymphocytes. J Leukoc Biol, 90 (4): 735-40. [PMID:21724806]
8. Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. (2016) Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Mol Pharmacol, 90 (3): 214-24. [PMID:27338081]
9. Wilde C, Fischer L, Lede V, Kirchberger J, Rothemund S, Schöneberg T, Liebscher I. (2016) The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. FASEB J, 30 (2): 666-73. [PMID:26499266]
