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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 652 | 19p13.12 | ADGRE3 | adhesion G protein-coupled receptor E3 | 8 |
| Previous and Unofficial Names |
| EMR3 (EGF-like module-containing, mucin-like, hormone receptor-like 3) |
| Database Links |
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| Specialist databases | |
| GPCRdb | agre3_human (Hs) |
| Other databases | |
| Alphafold | Q9BY15 (Hs) |
| Ensembl Gene | ENSG00000131355 (Hs) |
| Entrez Gene | 84658 (Hs) |
| Human Protein Atlas | ENSG00000131355 (Hs) |
| KEGG Gene | hsa:84658 (Hs) |
| OMIM | 606101 (Hs) |
| Pharos | Q9BY15 (Hs) |
| RefSeq Nucleotide | NM_032571 (Hs) |
| RefSeq Protein | NP_115960 (Hs) |
| UniProtKB | Q9BY15 (Hs) |
| Wikipedia | ADGRE3 (Hs) |
| Agonist Comments | ||
| No ligands identified: orphan receptor. |
| Immuno Process Associations | ||
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| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| General Comments |
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ADGRE3 (adhesion G protein-coupled receptor E3, formerly known as EMR3: EGF-like module containing, mucin-like, hormone receptor-like 3) is an orphan receptor that belongs to Family II Adhesion-GPCRs together with ADGRE5 and ADGRE1, ADGRE2 and ADGRE4 [1,3]. The genes of Family II Adhesion-GPCRs are syntenically clustered on human chromosome 19 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [4]. No mouse or rat ADGRE3 orthologues exist. Full coding sequence human cDNA is publicly available, IMAGE:7211798 [5] in mammalian expression vector pCDNA3.1. Clone matches RefSeq and human reference genomic sequence. |
1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
2. Kane AJ, Sughrue ME, Rutkowski MJ, Phillips JJ, Parsa AT. (2010) EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Neuroreport, 21 (16): 1018-22. [PMID:20827226]
3. Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. (2004) The EGF-TM7 family: a postgenomic view. Immunogenetics, 55 (10): 655-66. [PMID:14647991]
4. Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J. (2006) An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J, 20 (14): 2582-4. [PMID:17068111]
5. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]
6. Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J Leukoc Biol, 81 (2): 440-8. [PMID:17108056]
7. Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF, Friedman O, Kita H. (2010) Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE, 5 (7): e11450. [PMID:20625511]
8. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. (2001) Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem, 276 (22): 18863-70. [PMID:11279179]
