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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 797 | 3q12.2 | ADGRG7 | adhesion G protein-coupled receptor G7 | 5 |
| Mouse | 7 | 785 | 16 C1.1 | Adgrg7 | adhesion G protein-coupled receptor G7 | |
| Rat | 7 | 785 | 11q12 | Adgrg7 | adhesion G protein-coupled receptor G7 | |
| Previous and Unofficial Names |
| GPR128 (G protein-coupled receptor 128) |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrg7_human (Hs), agrg7_mouse (Mm) |
| Other databases | |
| Alphafold | Q96K78 (Hs), Q8BM96 (Mm) |
| Ensembl Gene | ENSG00000144820 (Hs), ENSMUSG00000022755 (Mm), ENSRNOG00000001634 (Rn) |
| Entrez Gene | 84873 (Hs), 239853 (Mm), 304014 (Rn) |
| Human Protein Atlas | ENSG00000144820 (Hs) |
| KEGG Gene | hsa:84873 (Hs), mmu:239853 (Mm), rno:304014 (Rn) |
| OMIM | 612307 (Hs) |
| Pharos | Q96K78 (Hs) |
| RefSeq Nucleotide | NM_032787 (Hs), NM_172825 (Mm), NM_001107098 (Rn) |
| RefSeq Protein | NP_116176 (Hs), NP_766413 (Mm), NP_001100568 (Rn) |
| UniProtKB | Q96K78 (Hs), Q8BM96 (Mm) |
| Wikipedia | ADGRG7 (Hs) |
| Agonist Comments | ||
| No ligands identified: orphan receptor. |
| Tissue Distribution
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| Expression Datasets |
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| Physiological Consequences of Altering Gene Expression
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| Gene Expression and Pathophysiology Comments | |
| Fusion to TFG, a target of chromosome translocations in lymphoma and soft tissue tumors in healthy donors [2-3]. |
| General Comments |
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ADGRG7 (formerly GPR128) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1-6 [4]. Full coding sequence human cDNA is publicly available, IMAGE:7447864 [7] in the mammalian expression vector pCDNA3.1. It has two silent changes compared to the RefSeq and reference human genomic sequence and has the more common (K151) allele of known SNP rs1144122. Also IMAGE:8322503 [7] in pCR4-TOPO with reversed insert has the same K151 allele but without the two silent changes. In lymphoma and soft tissue tumors, TFG fuses to ADGRG7. The downstream mechanism is not yet known [2]. |
1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
2. Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, Reiter A, Schreiber S, Cross NC. (2010) TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. Haematologica, 95 (1): 20-6. [PMID:19797732]
3. Ernst T, Chase A, Zoi K, Waghorn K, Hidalgo-Curtis C, Score J, Jones A, Grand F, Reiter A, Hochhaus A et al.. (2010) Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. Haematologica, 95 (9): 1473-80. [PMID:20421268]
4. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]
5. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]
6. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J, 19 (10): 1356-8. [PMID:15955843]
7. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]
8. Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y et al.. (2014) Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. World J Gastroenterol, 20 (2): 498-508. [PMID:24574718]
