Gene and Protein Information
Adhesion G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	708	6p12.3	ADGRF2P	adhesion G protein-coupled receptor F2, pseudogene
Mouse	7	644	17 B3	Adgrf2	adhesion G protein-coupled receptor F2
Rat	7	650	9q12	Adgrf2	adhesion G protein-coupled receptor F2

Previous and Unofficial Names

adhesion G protein-coupled receptor F2 | GPR111 (G protein-coupled receptor 111) | PGR20

Database Links
Specialist databases
GPCRdb	agrf2_human (Hs)
Other databases
Alphafold	Q8IZF7 (Hs)
ChEMBL Target	CHEMBL4523892 (Hs)
Ensembl Gene	ENSG00000164393 (Hs), ENSMUSG00000057899 (Mm), ENSRNOG00000025603 (Rn)
Entrez Gene	222611 (Hs), 435529 (Mm), 301269 (Rn)
Human Protein Atlas	ENSG00000164393 (Hs)
KEGG Gene	hsa:222611 (Hs), mmu:435529 (Mm), rno:301269 (Rn)
Pharos	Q8IZF7 (Hs)
RefSeq Nucleotide	NM_153839 (Hs), NM_001033493 (Mm)
RefSeq Protein	NP_722581 (Hs), NP_001028665 (Mm)
UniProtKB	Q8IZF7 (Hs)
Wikipedia	ADGRF2P (Hs)

Agonist Comments

No ligands identified: orphan receptor.

Tissue Distribution
Heart, skin, spleen, testis, brain, tongue, esophagus, forestomach Species:  Mouse Technique:  RT-PCR and LacZ insertion References:  3

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Functions
Skin barrier assay Species:  Mouse Tissue:  Skin References:  3

Physiological Consequences of Altering Gene Expression Comments

Adgrf2 knockout mice do not show defects in development or fertility [3].

General Comments

ADGRF2 (formerly GPR111) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF1 and ADGRF3-5 [1]. The genes of Family VI Adhesion-GPCRs except ADGRF3 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [3]. Original gene prediction [2] failed to predict several exons at both the 5' and 3' ends and included one exon of ADGRF2 in the prediction of ADGRF4 which is the adjacent gene. A rat cDNA similar to the mouse cDNA AK142836 can be predicted with an open reading frame of 650 amino acids.