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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 549 | 16q21 | ADGRG3 | adhesion G protein-coupled receptor G3 | 4 |
| Mouse | 7 | 542 | 8 C5 | Adgrg3 | adhesion G protein-coupled receptor G3 | |
| Rat | 7 | 547 | 19q13 | Adgrg3 | adhesion G protein-coupled receptor G3 | |
| Previous and Unofficial Names |
| GPR97 (G protein-coupled receptor 97) | Pb99 | PGR26 |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrg3_human (Hs), agrg3_mouse (Mm) |
| Other databases | |
| Alphafold | Q86Y34 (Hs), Q8R0T6 (Mm) |
| ChEMBL Target | CHEMBL3559707 (Hs) |
| Ensembl Gene | ENSG00000182885 (Hs), ENSMUSG00000060470 (Mm), ENSRNOG00000014896 (Rn) |
| Entrez Gene | 222487 (Hs), 54672 (Mm), 291854 (Rn) |
| Human Protein Atlas | ENSG00000182885 (Hs) |
| KEGG Gene | hsa:222487 (Hs), mmu:54672 (Mm), rno:291854 (Rn) |
| Pharos | Q86Y34 (Hs) |
| RefSeq Nucleotide | NM_170776 (Hs), NM_173036 (Mm) |
| RefSeq Protein | NP_740746 (Hs), NP_766624 (Mm) |
| UniProtKB | Q86Y34 (Hs), Q8R0T6 (Mm) |
| Wikipedia | ADGRG3 (Hs) |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Antagonist Comments | ||
| Treatment with pertussis toxin abolished the agonist-like effect of treatment with beclomethasone dipropionate [5]. |
| Immunopharmacology Comments |
| ADGRG3 is expressed by immune cells. It is required for proper B cell development in the spleen [10], and has been shown to regulate macrophage-mediated local inflammation in obesity-relevant tissues in rodent models [8]. |
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
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Gs family Gi/Go family |
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| Comments: ADGRG3 (GPR97) requires chimeric protein Gqo3 to induce inositol phosphate accumulation, indicating it primarily couples to Gαo-protein [5]. A recent study showed that GPR97 conducts Gαs/cAMP signaling, while a CTF-only mutant or crosslinking of the receptor triggered Gαo/i/ERK/NF-κB signaling [6]. | |
| References: 5-6 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Consequences of Altering Gene Expression
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| Physiological Consequences of Altering Gene Expression Comments | ||||||||||
| Adgrg3 knockout mice do not show defects in lymphocyte development [9]. | ||||||||||
| General Comments |
| ADGRG3 (formerly GPR97) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1, 2, and 4-7 [3]. The genes of ADGRG1, ADGRG3 and ADGRG5 are syntenically clustered on human chromosome 16 and mouse chromosome 8 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [7]. Antibody ligation of GPR97 increased neutrophil reactive oxygen species production and proteolytic enzyme activity, which is accompanied by an increase in mitogen-activated protein kinases and IκBα phosphorylation [6]. |
1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
2. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. (2007) Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene, 387 (1-2): 38-48. [PMID:17056209]
3. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]
4. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]
5. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. (2012) Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett, 586 (8): 1214-9. [PMID:22575658]
6. Hsiao CC, Chu TY, Wu CJ, van den Biggelaar M, Pabst C, Hébert J, Kuijpers TW, Scicluna BP, I KY, Chen TC et al.. (2018) The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. Front Immunol, 9: 2830. [PMID:30559745]
7. Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J. (2011) Specific expression of GPR56 by human cytotoxic lymphocytes. J Leukoc Biol, 90 (4): 735-40. [PMID:21724806]
8. Shi J, Zhang X, Wang S, Wang J, Du B, Wang Z, Liu M, Jiang W, Qian M, Ren H. (2016) Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice. Sci Rep, 6: 24649. [PMID:27089991]
9. Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM et al.. (2000) Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol, 20 (12): 4405-10. [PMID:10825203]
10. Wang JJ, Zhang LL, Zhang HX, Shen CL, Lu SY, Kuang Y, Wan YH, Wang WG, Yan HM, Dang SY et al.. (2013) Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Cell Death Dis, 4: e853. [PMID:24113187]
target has curated data in GtoImmuPdb
