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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 886 | 19p13.3-p13.2 | ADGRE1 | adhesion G protein-coupled receptor E1 | 2 |
| Mouse | 7 | 931 | 17 29.8 cM | Adgre1 | adhesion G protein-coupled receptor E1 | |
| Rat | 7 | 932 | 9q12 | Adgre1 | adhesion G protein-coupled receptor E1 | 17 |
| Previous and Unofficial Names |
| EMR1 (EGF-like module-containing, mucin-like, hormone receptor-like 1) |
| Database Links |
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| Specialist databases | |
| GPCRdb | agre1_human (Hs), agre1_rat (Rn) |
| Other databases | |
| Alphafold | Q14246 (Hs), Q3U9R0 (Mm), Q5Y4N8 (Rn) |
| Ensembl Gene | ENSG00000174837 (Hs), ENSMUSG00000004730 (Mm), ENSRNOG00000046254 (Rn) |
| Entrez Gene | 2015 (Hs), 13733 (Mm), 316137 (Rn) |
| Human Protein Atlas | ENSG00000174837 (Hs) |
| KEGG Gene | hsa:2015 (Hs), mmu:13733 (Mm), rno:316137 (Rn) |
| OMIM | 600493 (Hs) |
| Pharos | Q14246 (Hs) |
| RefSeq Nucleotide | NM_001974 (Hs), NM_001256255 (Hs), NM_001256254 (Hs), NM_001256252 (Hs), NM_001256253 (Hs), NM_010130 (Mm), NM_001007557 (Rn) |
| RefSeq Protein | NP_001243182 (Hs), NP_001243181 (Hs), NP_001243183 (Hs), NP_001243184 (Hs), NP_001965 (Hs), NP_034260 (Mm), NP_001007558 (Rn) |
| UniProtKB | Q14246 (Hs), Q3U9R0 (Mm), Q5Y4N8 (Rn) |
| Wikipedia | ADGRE1 (Hs) |
| Agonist Comments | ||
| No ligands identified: orphan receptor. |
| Immuno Process Associations | ||
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| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
| ADGRE1 and F4/80 are human and mouse orthologous genes, respectively. However, the two receptors have very different tissue distribution/cell expression patterns. F4/80 is a pan-macrophage marker, ubiquitously expressed in most, if not all, mouse resident tissue macrophages. F4/80 expression is also detected in eosinophils. On the other hand, ADGRE1 is restrictedly expressed in human eosinophilic granulocytes, but not monocytes, macrophages or myeloid dendritic cells. | ||||||||
| Expression Datasets |
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||
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| Biologically Significant Variants
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| General Comments |
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ADGRE1 (adhesion G protein-coupled receptor E1, formerly known as EMR1: EGF-like module containing, mucin-like, hormone receptor-like 1) is an orphan receptor that belongs to Family II Adhesion-GPCRs together with ADGRE5 and ADGRE2-4 [3,8]. The genes of Family II Adhesion-GPCRs are syntenically clustered on human chromosome 19 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [9]. The mouse gene is localized on chromosome 17 [18]. There are 14 well characterised amino acid-changing SNPs. Full coding sequence human cDNA is publicly available, IMAGE:7447856 [11] in mammalian expression vector pCDNA3.1. This clone differs from the RefSeq and reference genomic sequence at three known SNPs and has the more common allele at each, Val424, Gln496 and Val539. |
1. Austyn JM, Gordon S. (1981) F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol, 11 (10): 805-15. [PMID:7308288]
2. Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M. (1995) EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. Genomics, 26 (2): 334-44. [PMID:7601460]
3. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
4. Gordon S, Hamann J, Lin HH, Stacey M. (2011) F4/80 and the related adhesion-GPCRs. Eur J Immunol, 41 (9): 2472-6. [PMID:21952799]
5. Gordon S, Lawson L, Rabinowitz S, Crocker PR, Morris L, Perry VH. (1992) Antigen markers of macrophage differentiation in murine tissues. Curr Top Microbiol Immunol, 181: 1-37. [PMID:1424778]
6. Gordon S, Perry VH, Rabinowitz S, Chung LP, Rosen H. (1988) Plasma membrane receptors of the mononuclear phagocyte system. J Cell Sci Suppl, 9: 1-26. [PMID:3077135]
7. Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ. (2007) EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. Eur J Immunol, 37 (10): 2797-802. [PMID:17823986]
8. Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. (2004) The EGF-TM7 family: a postgenomic view. Immunogenetics, 55 (10): 655-66. [PMID:14647991]
9. Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J. (2006) An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J, 20 (14): 2582-4. [PMID:17068111]
10. Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M et al.. (2014) The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders. J Allergy Clin Immunol, 133 (5): 1439-47, 1447.e1-8. [PMID:24530099]
11. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]
12. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med, 201 (10): 1615-25. [PMID:15883173]
13. Lin HH, Stacey M, Stein-Streilein J, Gordon S. (2010) F4/80: the macrophage-specific adhesion-GPCR and its role in immunoregulation. Adv Exp Med Biol, 706: 149-56. [PMID:21618834]
14. Martinez-Pomares L, Platt N, McKnight AJ, da Silva RP, Gordon S. (1996) Macrophage membrane molecules: markers of tissue differentiation and heterogeneity. Immunobiology, 195 (4-5): 407-16. [PMID:8933147]
15. McGarry MP, Stewart CC. (1991) Murine eosinophil granulocytes bind the murine macrophage-monocyte specific monoclonal antibody F4/80. J Leukoc Biol, 50 (5): 471-8. [PMID:1721083]
16. McKnight AJ, Gordon S. (1998) The EGF-TM7 family: unusual structures at the leukocyte surface. J Leukoc Biol, 63 (3): 271-80. [PMID:9500513]
17. McKnight AJ, Macfarlane AJ, Dri P, Turley L, Willis AC, Gordon S. (1996) Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem, 271 (1): 486-9. [PMID:8550607]
18. McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S. (1997) Chromosome mapping of the Emr1 gene. Mamm Genome, 8 (12): 946. [PMID:9383301]
19. Schaller E, Macfarlane AJ, Rupec RA, Gordon S, McKnight AJ, Pfeffer K. (2002) Inactivation of the F4/80 glycoprotein in the mouse germ line. Mol Cell Biol, 22 (22): 8035-43. [PMID:12391169]
