Gene and Protein Information
Adhesion G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	3080	Xq26.3	ADGRG4	adhesion G protein-coupled receptor G4
Mouse	7	3073	X A6	Adgrg4	adhesion G protein-coupled receptor G4
Rat	7	2823	Xq36	Gpr112l	G protein-coupled receptor 112-like

Previous and Unofficial Names

GPR112 (G protein-coupled receptor 112)

Database Links
Specialist databases
GPCRdb	agrg4_human (Hs)
Other databases
Alphafold	Q8IZF6 (Hs), B7ZCC9 (Mm)
Ensembl Gene	ENSG00000156920 (Hs), ENSMUSG00000053852 (Mm)
Entrez Gene	139378 (Hs), 236798 (Mm), 302860 (Rn)
Human Protein Atlas	ENSG00000156920 (Hs)
KEGG Gene	hsa:139378 (Hs), mmu:236798 (Mm), rno:302860 (Rn)
Pharos	Q8IZF6 (Hs)
RefSeq Nucleotide	NM_153834 (Hs)
RefSeq Protein	NP_722576 (Hs)
UniProtKB	Q8IZF6 (Hs), B7ZCC9 (Mm)
Wikipedia	ADGRG4 (Hs)

Agonist Comments

No ligands identified: orphan receptor.

Tissue Distribution
Mammary gland, kidney, blood vessel, retina, testis Species:  Human Technique:  Microarray analysis and EST References:  1,3,5
Enterochromaffin cells of normal ileal mucosa, upregulated in related primary neuroendocrine carcinoma and liver metastasis Species:  Human Technique:  Microarray analysis and RT-PCR References:  5
Unigene expression profile: kidney and embryonic carcinoma. Species:  Mouse Technique:  References:
Mucosal layers of gastrointestinal tract, with highest level of expression in the duodenum Species:  Mouse Technique:  RT-PCR References:  4

General Comments

ADGRG4 (formerly GPR112) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1-3 and ADGRG5-7 [2]. ADGRG4 was found to contain a laminin_G/pentraxin (PTX) domain along with the GPS motif. The original gene prediction [3] failed to predict the first and last coding exons. There are five well characterised amino acid-changing SNPs as well as a number of reported amino acid-changing SNPs which are not confirmed. Mouse RefSeq NM_001033327.1 is based on cDNAs which cover only the last 5 exons.