Gene and Protein Information
Adhesion G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	1079	2p23.3	ADGRF3	adhesion G protein-coupled receptor F3
Mouse	7	991	5 B1	Adgrf3	adhesion G protein-coupled receptor F3	5
Rat	7	992	6q14	Adgrf3	adhesion G protein-coupled receptor F3

Previous and Unofficial Names

GPR113 (G protein-coupled receptor 113) | PGR23

Database Links
Specialist databases
GPCRdb	agrf3_human (Hs), agrf3_mouse (Mm)
Other databases
Alphafold	Q8IZF5 (Hs), Q58Y75 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4523891 (Hs)
Ensembl Gene	ENSG00000173567 (Hs), ENSMUSG00000067642 (Mm), ENSRNOG00000024766 (Rn)
Entrez Gene	165082 (Hs), 381628 (Mm), 298857 (Rn)
Human Protein Atlas	ENSG00000173567 (Hs)
KEGG Gene	hsa:165082 (Hs), mmu:381628 (Mm), rno:298857 (Rn)
Pharos	Q8IZF5 (Hs)
RefSeq Nucleotide	NM_153835 (Hs), NM_001014394 (Mm)
RefSeq Protein	NP_722577 (Hs), NP_001014416 (Mm)
UniProtKB	Q8IZF5 (Hs), Q58Y75 (Mm)
Wikipedia	ADGRF3 (Hs)

Agonist Comments

No ligands identified: orphan receptor.

Tissue Distribution
Kidney (cortex and medulla), small bowel, pancreas, also expressed in small bowel and pancreatic neuroendocrine tumor cells Species:  Human Technique:  Microarray analysis and RT-PCR References:  1,4
Testis and taste receptor cells in circumvalate papillae Species:  Mouse Technique:  Northern blot, RT-PCR and in situ hybrisation References:  5

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

General Comments

ADGRF3 (formerly GPR113) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF1, 2 , 4 and 5 [2]. Gene prediction [3] has first two exons which are not supported by cDNAs and fails to predict the last two exons. Available human cDNAs show various splicing patterns involving the first 7 exons. RefSeq NP_722577.2 is based on a variant which lacks two coding exons that are present in several cDNAs. Inclusion of those two exons would increase protein size to 1013 amino acids. The N terminus of ADGRF3 contains a GPCR proteolysis site (GPS) and a hormone receptor motif (HRM).