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ADGRF3

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Target not currently curated in GtoImmuPdb

Target id: 193

Nomenclature: ADGRF3

Family: Adhesion Class GPCRs

Gene and Protein Information Click here for help
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1079 2p23.3 ADGRF3 adhesion G protein-coupled receptor F3
Mouse 7 991 5 B1 Adgrf3 adhesion G protein-coupled receptor F3 5
Rat 7 992 6q14 Adgrf3 adhesion G protein-coupled receptor F3
Previous and Unofficial Names Click here for help
GPR113 (G protein-coupled receptor 113) | PGR23
Database Links Click here for help
Specialist databases
GPCRDB agrf3_human (Hs), agrf3_mouse (Mm)
Other databases
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution Click here for help
Kidney (cortex and medulla), small bowel, pancreas, also expressed in small bowel and pancreatic neuroendocrine tumor cells
Species:  Human
Technique:  Microarray analysis and RT-PCR
References:  1,4
Testis and taste receptor cells in circumvalate papillae
Species:  Mouse
Technique:  Northern blot, RT-PCR and in situ hybrisation
References:  5
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
ADGRF3 (formerly GPR113) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF1, 2 , 4 and 5 [2].

Gene prediction [3] has first two exons which are not supported by cDNAs and fails to predict the last two exons. Available human cDNAs show various splicing patterns involving the first 7 exons. RefSeq NP_722577.2 is based on a variant which lacks two coding exons that are present in several cDNAs. Inclusion of those two exons would increase protein size to 1013 amino acids. The N terminus of ADGRF3 contains a GPCR proteolysis site (GPS) and a hormone receptor motif (HRM).

References

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1. Carr JC, Boese EA, Spanheimer PM, Dahdaleh FS, Martin M, Calva D, Schafer B, Thole DM, Braun T, O'Dorisio TM et al.. (2012) Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling. Surgery, 152 (6): 998-1007. [PMID:23158174]

2. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun., 301 (3): 725-34. [PMID:12565841]

3. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett., 531 (3): 407-14. [PMID:12435584]

4. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J., 19 (10): 1356-8. [PMID:15955843]

5. LopezJimenez ND, Sainz E, Cavenagh MM, Cruz-Ithier MA, Blackwood CA, Battey JF, Sullivan SL. (2005) Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells. Genomics, 85 (4): 472-82. [PMID:15780750]

Contributors

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